TY - JOUR
T1 - Emotional dysfunction in Parkinson's disease
AU - Blonder, Lee X.
AU - Slevin, John T.
PY - 2011
Y1 - 2011
N2 - In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinson patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways. There is also evidence suggesting that the interaction between serotonin and dopamine systems is important in the understanding and treatment of mood disorders in Parkinson's disease. In this review we discuss the neuropsychiatric abnormalities that accompany Parkinson's disease and describe their neuropsychological, neuropharmacologic, and neuroimaging concomitants.
AB - In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinson patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways. There is also evidence suggesting that the interaction between serotonin and dopamine systems is important in the understanding and treatment of mood disorders in Parkinson's disease. In this review we discuss the neuropsychiatric abnormalities that accompany Parkinson's disease and describe their neuropsychological, neuropharmacologic, and neuroimaging concomitants.
KW - Parkinson's disease
KW - anxiety
KW - depression
KW - emotion
KW - neuropsychological impairment
UR - http://www.scopus.com/inward/record.url?scp=80052646469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052646469&partnerID=8YFLogxK
U2 - 10.3233/BEN-2011-0329
DO - 10.3233/BEN-2011-0329
M3 - Article
C2 - 21876260
AN - SCOPUS:80052646469
SN - 0953-4180
VL - 24
SP - 201
EP - 217
JO - Behavioural Neurology
JF - Behavioural Neurology
IS - 3
ER -