EnABLing Cathepsin-Driven Melanoma Metastasis

Rakshamani Tripathi, Rina Plattner

Research output: Contribution to journalArticlepeer-review

Abstract

Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

Original languageEnglish
Article numbere1458016
JournalMolecular and Cellular Oncology
Volume5
Issue number4
DOIs
StatePublished - Jul 4 2018

Bibliographical note

Funding Information:
This work was supported by NIH grants R01CA116784 and R01CA166499, and by a Markey Cancer Foundation Women Strong Award to R.P. The Research Communications Office of the Markey and Center (P30CA177558) supported this work and contributed to the figure.

Funding Information:
HHS j NIH j National Cancer Institute (NCI), HHS j NIH j National Cancer Institute (NCI). This work was supported by NIH grants R01CA116784 and R01CA166499, and by a Markey Cancer Foundation Women Strong Award to R.P.

Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.

Keywords

  • ABL1
  • ABL2
  • Abl
  • Arg
  • ETS1
  • NF-κB
  • RELA
  • SP1
  • cathepsin
  • cysteine cathepsins

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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