EnABLing Cathepsin-Driven Melanoma Metastasis

Rakshamani Tripathi; Rina Plattner

doi:10.1080/23723556.2018.1458016

EnABLing Cathepsin-Driven Melanoma Metastasis

Rakshamani Tripathi, Rina Plattner

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

Original language	English
Article number	e1458016
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2018.1458016
State	Published - Jul 4 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.

Keywords

ABL1
ABL2
Abl
Arg
ETS1
NF-κB
RELA
SP1
cathepsin
cysteine cathepsins

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2018.1458016

Cite this

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title = "EnABLing Cathepsin-Driven Melanoma Metastasis",

abstract = "Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.",

keywords = "ABL1, ABL2, Abl, Arg, ETS1, NF-κB, RELA, SP1, cathepsin, cysteine cathepsins",

author = "Rakshamani Tripathi and Rina Plattner",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Taylor & Francis Group, LLC.",

year = "2018",

month = jul,

day = "4",

doi = "10.1080/23723556.2018.1458016",

language = "English",

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TY - JOUR

T1 - EnABLing Cathepsin-Driven Melanoma Metastasis

AU - Tripathi, Rakshamani

AU - Plattner, Rina

PY - 2018/7/4

Y1 - 2018/7/4

N2 - Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

AB - Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

KW - ABL1

KW - ABL2

KW - Abl

KW - Arg

KW - ETS1

KW - NF-κB

KW - RELA

KW - SP1

KW - cathepsin

KW - cysteine cathepsins

UR - http://www.scopus.com/inward/record.url?scp=85052662257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052662257&partnerID=8YFLogxK

U2 - 10.1080/23723556.2018.1458016

DO - 10.1080/23723556.2018.1458016

M3 - Article

AN - SCOPUS:85052662257

VL - 5

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 4

M1 - e1458016

ER -

EnABLing Cathepsin-Driven Melanoma Metastasis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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