EnABLing Cathepsin-Driven Melanoma Metastasis

Rakshamani Tripathi, Rina Plattner

Research output: Contribution to journalArticlepeer-review


Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.

Original languageEnglish
Article numbere1458016
JournalMolecular and Cellular Oncology
Issue number4
StatePublished - Jul 4 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.


  • ABL1
  • ABL2
  • Abl
  • Arg
  • ETS1
  • NF-κB
  • RELA
  • SP1
  • cathepsin
  • cysteine cathepsins

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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