Enabling technologies in discovery: The 2009 Nobel Prize and its implications in antibiotic design

Yinan Wei; Sylvia Daunert

doi:10.1007/s00216-009-3427-z

Enabling technologies in discovery: The 2009 Nobel Prize and its implications in antibiotic design

Yinan Wei
, Sylvia Daunert

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The 2009 Nobel Prize in Chemistry recognized researchers for the illustration of the structure and function of the ribosome, the protein production machinery that translates the DNA blueprint. Ada E. Yonath, Weizmann Institute of Science with the coworkers obtained crystals from the 50S subunit from H. marismortui with a diffraction resolution of 3 Å. The development of several analytical methods such as the employment of CCD area-detectors for precise and automated analysis of X-ray diffraction patterns ensures the advancement in the researches. Several antibiotics based on the differences of the structures of the prokaryotic and eukaryotic ribosomes to selectively or preferentially target the prokaryotic ribosome to attack microorganisms and disrupt their protein synthesis. The advanced analytical science is focused on the design and development of enabling techniques and instrumentation for targeted applications that are employed to study the structure of proteins.

Original language	English
Pages (from-to)	1623-1626
Number of pages	4
Journal	Analytical and Bioanalytical Chemistry
Volume	396
Issue number	5
DOIs	https://doi.org/10.1007/s00216-009-3427-z
State	Published - Mar 2010

Bibliographical note

Funding Information:
Acknowledgements Sylvia Daunert acknowledges support from the National Science Foundation, the National Institutes of Health, and the National Institutes of Health Sciences. She is also grateful for a Gill Eminent Professorship at the University of Kentucky.

Funding

Acknowledgements Sylvia Daunert acknowledges support from the National Science Foundation, the National Institutes of Health, and the National Institutes of Health Sciences. She is also grateful for a Gill Eminent Professorship at the University of Kentucky.

Funders	Funder number
National Institutes of Health/National Institute of Environmental Health Sciences
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China
National Institutes of Health (NIH)
National Institute of General Medical Sciences	R01GM047915

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

Access to Document

10.1007/s00216-009-3427-z

Cite this

@article{0da75acb10a54f6e821e98c71413babc,

title = "Enabling technologies in discovery: The 2009 Nobel Prize and its implications in antibiotic design",

abstract = "The 2009 Nobel Prize in Chemistry recognized researchers for the illustration of the structure and function of the ribosome, the protein production machinery that translates the DNA blueprint. Ada E. Yonath, Weizmann Institute of Science with the coworkers obtained crystals from the 50S subunit from H. marismortui with a diffraction resolution of 3 {\AA}. The development of several analytical methods such as the employment of CCD area-detectors for precise and automated analysis of X-ray diffraction patterns ensures the advancement in the researches. Several antibiotics based on the differences of the structures of the prokaryotic and eukaryotic ribosomes to selectively or preferentially target the prokaryotic ribosome to attack microorganisms and disrupt their protein synthesis. The advanced analytical science is focused on the design and development of enabling techniques and instrumentation for targeted applications that are employed to study the structure of proteins.",

author = "Yinan Wei and Sylvia Daunert",

note = "Funding Information: Acknowledgements Sylvia Daunert acknowledges support from the National Science Foundation, the National Institutes of Health, and the National Institutes of Health Sciences. She is also grateful for a Gill Eminent Professorship at the University of Kentucky.",

year = "2010",

month = mar,

doi = "10.1007/s00216-009-3427-z",

language = "English",

volume = "396",

pages = "1623--1626",

number = "5",

}

TY - JOUR

T1 - Enabling technologies in discovery

T2 - The 2009 Nobel Prize and its implications in antibiotic design

AU - Wei, Yinan

AU - Daunert, Sylvia

N1 - Funding Information: Acknowledgements Sylvia Daunert acknowledges support from the National Science Foundation, the National Institutes of Health, and the National Institutes of Health Sciences. She is also grateful for a Gill Eminent Professorship at the University of Kentucky.

PY - 2010/3

Y1 - 2010/3

N2 - The 2009 Nobel Prize in Chemistry recognized researchers for the illustration of the structure and function of the ribosome, the protein production machinery that translates the DNA blueprint. Ada E. Yonath, Weizmann Institute of Science with the coworkers obtained crystals from the 50S subunit from H. marismortui with a diffraction resolution of 3 Å. The development of several analytical methods such as the employment of CCD area-detectors for precise and automated analysis of X-ray diffraction patterns ensures the advancement in the researches. Several antibiotics based on the differences of the structures of the prokaryotic and eukaryotic ribosomes to selectively or preferentially target the prokaryotic ribosome to attack microorganisms and disrupt their protein synthesis. The advanced analytical science is focused on the design and development of enabling techniques and instrumentation for targeted applications that are employed to study the structure of proteins.

AB - The 2009 Nobel Prize in Chemistry recognized researchers for the illustration of the structure and function of the ribosome, the protein production machinery that translates the DNA blueprint. Ada E. Yonath, Weizmann Institute of Science with the coworkers obtained crystals from the 50S subunit from H. marismortui with a diffraction resolution of 3 Å. The development of several analytical methods such as the employment of CCD area-detectors for precise and automated analysis of X-ray diffraction patterns ensures the advancement in the researches. Several antibiotics based on the differences of the structures of the prokaryotic and eukaryotic ribosomes to selectively or preferentially target the prokaryotic ribosome to attack microorganisms and disrupt their protein synthesis. The advanced analytical science is focused on the design and development of enabling techniques and instrumentation for targeted applications that are employed to study the structure of proteins.

UR - https://www.scopus.com/pages/publications/77949271608

UR - https://www.scopus.com/pages/publications/77949271608#tab=citedBy

U2 - 10.1007/s00216-009-3427-z

DO - 10.1007/s00216-009-3427-z

M3 - Article

C2 - 20127083

AN - SCOPUS:77949271608

SN - 1618-2642

VL - 396

SP - 1623

EP - 1626

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

IS - 5

ER -

Enabling technologies in discovery: The 2009 Nobel Prize and its implications in antibiotic design

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this