Endogenous cortisol exposure and declarative verbal memory: A longitudinal study of healthy older adults

Suzanne C. Segerstrom, Paul J. Geiger, Ian A. Boggero, Fredrick A. Schmitt, Sandra E. Sephton

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: Exposure to endogenous cortisol is associated with hippocampal degeneration and may contribute to problems with declarative memory, but effects of persistent versus phasic cortisol elevations have not been established. The present longitudinal investigation examined persistent individual differences and phasic changes in cortisol as they related to verbal memory, executive functions, and subjective cognitive function. Methods: Older adults (n = 132, aged 60-93 years) were followed up for up to 5 years. They were assessed annually for verbal memory and every 6 months for executive functions, subjective cognitive function, and cortisol area under the curve (averaged over 3 days). Results: In multilevel models, persistently but not phasically higher cortisol was associated with worse verbal memory in both learning (t(181) = 2.99, p = .003) and recall (t(280) = 3.10, p = .002). This effect withstood adjustment for stress, depression, metabolic health, and age. There was evidence for attenuated primacy in learning with higher persistent cortisol. Phasic increases in cortisol were not associated with changes in memory, and cortisol was not related to executive functions or subjective cognitive function. Conclusions: Higher secretion of cortisol may, over time, contribute to memory dysfunction in older adults.

Original languageEnglish
Pages (from-to)182-191
Number of pages10
JournalPsychosomatic Medicine
Issue number2
StatePublished - 2016

Bibliographical note

Publisher Copyright:
Copyright © 2015 by the American Psychosomatic Society.


  • Aging
  • Cortisol
  • Executive cognitive function
  • Serial position
  • Verbal memory

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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