High-throughput ligand displacement screens of a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily displace [3H]spermidine and [3H]MK-801 from their respective binding sites in rat brain homogenate. These data, coupled with their potent inhibition of spermidine-potentiated [3H]MK-801 binding, suggest that certain endogenous indoles may act as ligands to one or more polyamine binding sites in the brain, including those on the N-methyl-D-aspartate receptor complex.
|Number of pages||4|
|State||Published - Feb 2 2001|
Bibliographical noteFunding Information:
This investigation was supported by National Institutes of Health, National Research Service award DA07304 from the National Institute on Drug Abuse, American Foundation for Pharmaceutical Education Fellowships (A.K.B. and D.R.W.) and National Institute of Alcohol Abuse and Alcoholism Grant AA12600.
- Endogenous indole
- Polyamine recognition domain
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology