Endoscopic Ultrasound-Guided Confocal Laser Endomicroscopy Increases Accuracy of Differentiation of Pancreatic Cystic Lesions

Somashekar G. Krishna, Phil A. Hart, Ahmad Malli, Andrew J. Kruger, Sean T. McCarthy, Samer El-Dika, Jon P. Walker, Mary E. Dillhoff, Andrei Manilchuk, Carl R. Schmidt, Timothy M. Pawlik, Kyle Porter, Christina A. Arnold, Zobeida Cruz-Monserrate, Darwin L. Conwell

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Background & Aims: Imaging patterns from endoscopic ultrasound (EUS)-guided needle-based confocal laser endomicroscopy (nCLE) have been associated with specific pancreatic cystic lesions (PCLs). We compared the accuracy of EUS with nCLE in differentiating mucinous from nonmucinous PCLs with that of measurement of carcinoembryonic antigen (CEA) and cytology analysis. Methods: We performed a prospective study of 144 consecutive patients with a suspected PCL (≥20 mm) who underwent EUS with fine-needle aspiration of pancreatic cysts from June 2015 through December 2018 at a single center; 65 patients underwent surgical resection. Surgical samples were analyzed by histology (reference standard). During EUS, the needle with the miniprobe was placed in the cyst, which was analyzed by nCLE. Fluid was aspirated and analyzed for level of CEA and by cytology. We compared the accuracy of nCLE in differentiating mucinous from nonmucinous lesions with that of measurement of CEA and cytology analysis. Results: The mean size of dominant cysts was 36.4 ± 15.7 mm and the mean duration of nCLE imaging was 7.3 ± 2.8 min. Among the 65 subjects with surgically resected cysts analyzed histologically, 86.1% had at least 1 worrisome feature based on the 2012 Fukuoka criteria. Measurement of CEA and cytology analysis identified mucinous PCLs with 74% sensitivity, 61% specificity, and 71% accuracy. EUS with nCLE identified mucinous PCLs with 98% sensitivity, 94% specificity, and 97% accuracy. nCLE was more accurate in classifying mucinous vs nonmucinous cysts than the standard method (P <.001). The overall incidence of postprocedure acute pancreatitis was 3.5% (5 of 144); all episodes were mild, based on the revised Atlanta criteria. Conclusions: In a prospective study, we found that analysis of cysts by nCLE identified mucinous cysts with greater accuracy than measurement of CEA and cytology analysis. EUS with nCLE can be used to differentiate mucinous from nonmucinous PCLs. ClincialTrials.gov no: NCT02516488.

Original languageEnglish
Pages (from-to)432-440.e6
JournalClinical Gastroenterology and Hepatology
Volume18
Issue number2
DOIs
StatePublished - Feb 2020

Bibliographical note

Funding Information:
Funding This study was funded by an American College of Gastroenterology Clinical Research grant.

Publisher Copyright:
© 2020 AGA Institute

Keywords

  • Diagnosis
  • INDEX Study
  • Pancreatic Cancer
  • Pathology
  • Risk

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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