Endothelial uptake of fentanyl occurs by both diffusional and specific transporter pathways

Christopher M. Waters, Tom C. Krejcie, Michael J. Avram

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The mechanisms of the specific uptake of fentanyl were investigated using human lung microvascular endothelia cells. Cellular uptake of fentanyl was modeled with two pathways. Uptake by passive diffusion was characterized by rapid partitioning between the supernatant fluid and a cellular diffusion compartment using a partition coefficient. Specific uptake of fentanyl by a transporter was characterized by a rate constant for binding to the transporter. The results demonstrate that human lung microvascular endothelial cells are capable of active uptake and sequestering of fentanyl.

Original languageEnglish
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999


Conference1999 Bioengineering Conference
CityBig Sky, MT, USA

ASJC Scopus subject areas

  • General Engineering


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