Endothelins in regulating ovarian and oviductal function

Phillip J. Bridges, Jongki Cho, Chemyong Ko

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


In the last 30 years, remarkable progress has been made in our understanding of the biological role of endothelins in the regulation of reproductive function and fertility. A peptide hormone identified for its ability to regulate blood pressure has now been shown as a potent mediator of several reproductive pathways. Ligand- and receptor-specific roles have been identified and/or postulated during follicular development and ovulation as well as in the function and regression of the corpus luteum. In this review we have attempted to organize endothelinmediated ovarian processes in a process-specific manner, rather than compile a review of ligand- or isoform-specific actions. Further, we have included a discussion on "postovarian" or oviductal function, as well as the future directions that we believe will increase our understanding of endothelin biology as a whole.

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number1
StatePublished - Jan 1 2011


  • Corpus Luteum
  • Endothelin
  • Follicle
  • Ovary
  • Oviduct
  • Ovulation
  • Review

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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