Engaging neuroscience to advance translational research in brain barrier biology

Edward A. Neuwelt; Björn Bauer; Christoph Fahlke; Gert Fricker; Constantino Iadecola; Damir Janigro; Luc Leybaert; Zoltán Molnár; Martha E. O'Donnell; John T. Povlishock; Norman R. Saunders; Frank Sharp; Danica Stanimirovic; Ryan J. Watts; Lester R. Drewes

doi:10.1038/nrn2995

Engaging neuroscience to advance translational research in brain barrier biology

Edward A. Neuwelt, Björn Bauer, Christoph Fahlke, Gert Fricker, Constantino Iadecola, Damir Janigro, Luc Leybaert, Zoltán Molnár, Martha E. O'Donnell, John T. Povlishock, Norman R. Saunders, Frank Sharp, Danica Stanimirovic, Ryan J. Watts, Lester R. Drewes

Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

490 Citations (SciVal)

Abstract

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

Original language	English
Pages (from-to)	169-182
Number of pages	14
Journal	Nature Reviews Neuroscience
Volume	12
Issue number	3
DOIs	https://doi.org/10.1038/nrn2995
State	Published - Mar 2011

Bibliographical note

Funding Information:
The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O’Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.

ASJC Scopus subject areas

General Neuroscience

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Neuwelt, E. A., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O'Donnell, M. E., Povlishock, J. T., Saunders, N. R., Sharp, F., Stanimirovic, D., Watts, R. J., & Drewes, L. R. (2011). Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews Neuroscience, 12(3), 169-182. https://doi.org/10.1038/nrn2995

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abstract = "The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.",

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note = "Funding Information: The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O{\textquoteright}Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.",

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Neuwelt, EA, Bauer, B, Fahlke, C, Fricker, G, Iadecola, C, Janigro, D, Leybaert, L, Molnár, Z, O'Donnell, ME, Povlishock, JT, Saunders, NR, Sharp, F, Stanimirovic, D, Watts, RJ & Drewes, LR 2011, 'Engaging neuroscience to advance translational research in brain barrier biology', Nature Reviews Neuroscience, vol. 12, no. 3, pp. 169-182. https://doi.org/10.1038/nrn2995

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AU - Janigro, Damir

AU - Leybaert, Luc

AU - Molnár, Zoltán

AU - O'Donnell, Martha E.

AU - Povlishock, John T.

AU - Saunders, Norman R.

AU - Sharp, Frank

AU - Stanimirovic, Danica

AU - Watts, Ryan J.

AU - Drewes, Lester R.

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Engaging neuroscience to advance translational research in brain barrier biology

Abstract

Bibliographical note

ASJC Scopus subject areas

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