Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

Stephanos Kyrkanides, M. Kerry O'Banion, Phyllis E. Whiteley, Jo Anne C. Daeschner, John A. Olschowka

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3 months) and aged (36 months) Fisher 344/Brown Norwegian F1 hybrid rats following cortical stab. Enhanced glial activation in older animals was accompanied by increased expression of a subset of inflammation-related mRNAs, including IL-1β, TNFα, IL-6, ICAM-1, inducible nitric oxide synthase (iNOS), metalloproteinase-9 (MMP-9), and complement 3α-chain 1 (C3α1). Recognition of these age-specific differences may guide development of novel treatment regimes for older individuals.

Original languageEnglish
Pages (from-to)269-277
Number of pages9
JournalJournal of Neuroimmunology
Volume119
Issue number2
DOIs
StatePublished - Oct 1 2001

Bibliographical note

Funding Information:
The authors thank Dr. Jose Freire, Susan Hansell, and Lee Trojanczyk for technical assistance, Dr. Amy H. Moore for advice on statistical analysis, and Dr. Sean Hurley for fruitful discussions. This work was supported in part by PHS grant NS33553 and a pilot grant from the Rochester Area Pepper Center (P60 AG10463).

Keywords

  • Aging
  • Astrocytes
  • Brain trauma
  • Microglia
  • Neurodegenerative disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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