Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

Stephanos Kyrkanides; M. Kerry O'Banion; Phyllis E. Whiteley; Jo Anne C. Daeschner; John A. Olschowka

doi:10.1016/S0165-5728(01)00404-0

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

Stephanos Kyrkanides, M. Kerry O'Banion, Phyllis E. Whiteley, Jo Anne C. Daeschner, John A. Olschowka

Oral Health Science

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3 months) and aged (36 months) Fisher 344/Brown Norwegian F1 hybrid rats following cortical stab. Enhanced glial activation in older animals was accompanied by increased expression of a subset of inflammation-related mRNAs, including IL-1β, TNFα, IL-6, ICAM-1, inducible nitric oxide synthase (iNOS), metalloproteinase-9 (MMP-9), and complement 3α-chain 1 (C3α1). Recognition of these age-specific differences may guide development of novel treatment regimes for older individuals.

Original language	English
Pages (from-to)	269-277
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/S0165-5728(01)00404-0
State	Published - Oct 1 2001

Bibliographical note

Funding Information:
The authors thank Dr. Jose Freire, Susan Hansell, and Lee Trojanczyk for technical assistance, Dr. Amy H. Moore for advice on statistical analysis, and Dr. Sean Hurley for fruitful discussions. This work was supported in part by PHS grant NS33553 and a pilot grant from the Rochester Area Pepper Center (P60 AG10463).

Keywords

Aging
Astrocytes
Brain trauma
Microglia
Neurodegenerative disease

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(01)00404-0

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abstract = "Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3 months) and aged (36 months) Fisher 344/Brown Norwegian F1 hybrid rats following cortical stab. Enhanced glial activation in older animals was accompanied by increased expression of a subset of inflammation-related mRNAs, including IL-1β, TNFα, IL-6, ICAM-1, inducible nitric oxide synthase (iNOS), metalloproteinase-9 (MMP-9), and complement 3α-chain 1 (C3α1). Recognition of these age-specific differences may guide development of novel treatment regimes for older individuals.",

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note = "Funding Information: The authors thank Dr. Jose Freire, Susan Hansell, and Lee Trojanczyk for technical assistance, Dr. Amy H. Moore for advice on statistical analysis, and Dr. Sean Hurley for fruitful discussions. This work was supported in part by PHS grant NS33553 and a pilot grant from the Rochester Area Pepper Center (P60 AG10463).",

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AU - Whiteley, Phyllis E.

AU - Daeschner, Jo Anne C.

AU - Olschowka, John A.

N1 - Funding Information: The authors thank Dr. Jose Freire, Susan Hansell, and Lee Trojanczyk for technical assistance, Dr. Amy H. Moore for advice on statistical analysis, and Dr. Sean Hurley for fruitful discussions. This work was supported in part by PHS grant NS33553 and a pilot grant from the Rochester Area Pepper Center (P60 AG10463).

PY - 2001/10/1

Y1 - 2001/10/1

N2 - Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3 months) and aged (36 months) Fisher 344/Brown Norwegian F1 hybrid rats following cortical stab. Enhanced glial activation in older animals was accompanied by increased expression of a subset of inflammation-related mRNAs, including IL-1β, TNFα, IL-6, ICAM-1, inducible nitric oxide synthase (iNOS), metalloproteinase-9 (MMP-9), and complement 3α-chain 1 (C3α1). Recognition of these age-specific differences may guide development of novel treatment regimes for older individuals.

AB - Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3 months) and aged (36 months) Fisher 344/Brown Norwegian F1 hybrid rats following cortical stab. Enhanced glial activation in older animals was accompanied by increased expression of a subset of inflammation-related mRNAs, including IL-1β, TNFα, IL-6, ICAM-1, inducible nitric oxide synthase (iNOS), metalloproteinase-9 (MMP-9), and complement 3α-chain 1 (C3α1). Recognition of these age-specific differences may guide development of novel treatment regimes for older individuals.

KW - Aging

KW - Astrocytes

KW - Brain trauma

KW - Microglia

KW - Neurodegenerative disease

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Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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