TY - JOUR
T1 - Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer
AU - Senthilnathan, Palaniyandi
AU - Padmavathi, Radhakrishnan
AU - Banu, Syed Mumtaz
AU - Sakthisekaran, Dhanapal
PY - 2006/2/25
Y1 - 2006/2/25
N2 - The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. In our previous study, we reported the antioxidant and anticarcinogenic effect of W. somnifera (L.) Dunal along with paclitaxel. Immune dysfunction has been found to be associated with cancer and chemotherapy. Benzo(a)pyrene induced cancer animals were treated with 400 mg/kg bodyweight of W. somnifera (L.) Dunal extract for 30 days significantly alters the levels of immunocompetent cells, immune complexes and immunoglobulins. Based on the data, the carcinogen as well as the paclitaxel affects the immune system, the toxic side effects on the immune system is more reversible and more controllable by W. somnifera (L.) Dunal. These results concluded the immunomodulatory activity of W. somnifera (L.) Dunal extract, which is a known immunomodulator in indigenous medicine.
AB - The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. In our previous study, we reported the antioxidant and anticarcinogenic effect of W. somnifera (L.) Dunal along with paclitaxel. Immune dysfunction has been found to be associated with cancer and chemotherapy. Benzo(a)pyrene induced cancer animals were treated with 400 mg/kg bodyweight of W. somnifera (L.) Dunal extract for 30 days significantly alters the levels of immunocompetent cells, immune complexes and immunoglobulins. Based on the data, the carcinogen as well as the paclitaxel affects the immune system, the toxic side effects on the immune system is more reversible and more controllable by W. somnifera (L.) Dunal. These results concluded the immunomodulatory activity of W. somnifera (L.) Dunal extract, which is a known immunomodulator in indigenous medicine.
KW - Benzo(a)pyrene
KW - Lung cancer
KW - Mice
KW - Paclitaxel
KW - Withania somnifera
UR - http://www.scopus.com/inward/record.url?scp=30944433774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30944433774&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2005.11.003
DO - 10.1016/j.cbi.2005.11.003
M3 - Article
C2 - 16375880
AN - SCOPUS:30944433774
SN - 0009-2797
VL - 159
SP - 180
EP - 185
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 3
ER -
