Enhancement of cyclopamine via conjugation with nonmetabolic sugars

Randal D. Goff, Jon S. Thorson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The Veratrum alkaloid cyclopamine, an inhibitor of cancer stem cell growth, was used as a representative scaffold to evaluate the inhibitory impact of glycosylation with a group of nonmetabolic saccharides, such as d-threose. In a five-step divergent process, a 32-member glycoside library was created and assayed to determine that glycosides of such sugars notably improved the GI 50 value of cyclopamine while metabolic sugars, such as d-glucose, did not.

Original languageEnglish
Pages (from-to)2454-2457
Number of pages4
JournalOrganic Letters
Issue number10
StatePublished - May 18 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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