The Veratrum alkaloid cyclopamine, an inhibitor of cancer stem cell growth, was used as a representative scaffold to evaluate the inhibitory impact of glycosylation with a group of nonmetabolic saccharides, such as d-threose. In a five-step divergent process, a 32-member glycoside library was created and assayed to determine that glycosides of such sugars notably improved the GI 50 value of cyclopamine while metabolic sugars, such as d-glucose, did not.
|Number of pages
|Published - May 18 2012
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry