Enhancing research data infrastructure to address the opioid epidemic: the Opioid Overdose Network (O2-Net)

Leslie A Lenert, Vivienne Zhu, Lindsey Jennings, Jenna L McCauley, Jihad S Obeid, Ralph Ward, Saeed Hassanpour, Lisa A Marsch, Michael Hogarth, Perry Shipman, Daniel R Harris, Jeffery C Talbert

Research output: Contribution to journalArticlepeer-review


Opioid Overdose Network is an effort to generalize and adapt an existing research data network, the Accrual to Clinical Trials (ACT) Network, to support design of trials for survivors of opioid overdoses presenting to emergency departments (ED). Four institutions (Medical University of South Carolina [MUSC], Dartmouth Medical School [DMS], University of Kentucky [UK], and University of California San Diego [UCSD]) worked to adapt the ACT network. The approach that was taken to enhance the ACT network focused on 4 activities: cloning and extending the ACT infrastructure, developing an e-phenotype and corresponding registry, developing portable natural language processing tools to enhance data capture, and developing automated documentation templates to enhance extended data capture. Overall, initial results suggest that tailoring of existing multipurpose federated research networks to specific tasks is feasible; however, substantial efforts are required for coordination of the subnetwork and development of new tools for extension of available data. The initial output of the project was a new approach to decision support for the prescription of naloxone for home use in the ED, which is under further study within the network.

Original languageEnglish
Pages (from-to)ooac055
JournalJAMIA Open
Issue number2
StatePublished - Jul 2022

Bibliographical note

© The Author(s) 2022. Published by Oxford University Press on behalf of the American Medical Informatics Association.


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