Enhancing the divergent activities of betulinic acid via neoglycosylation

Randal D. Goff, Jon S. Thorson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

(Chemical Equation Presented) Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, on the basis of the appended sugar, into two distinct compound subsets.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalOrganic Letters
Volume11
Issue number2
DOIs
StatePublished - Jan 15 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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