Enlarged perivascular space burden predicts declines in cognitive and functional performance

T. J. Libecap, Colleen A. Pappas, Christopher E. Bauer, Valentinos Zachariou, Flavius D. Raslau, Brian T. Gold

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We evaluated the relationship between baseline enlarged perivascular space (ePVS) burden and later cognitive decline. Methods: 83 community-dwelling, older adults (aged 56–86) completed three annual cognitive assessments that included the Clinical Dementia Rating (CDR®) Dementia Staging Instrument Sum of Boxes (CDR-SB) and composite measures of executive function and episodic memory. An MRI scan at baseline was used to count ePVS in the basal ganglia and centrum semiovale. Mixed effects models were run with ePVS as the predictor variable and cognitive measures as the dependent variable. Covariates included age, sex, education, cerebral small vessel disease (cSVD) risk factors, and cSVD neuroimaging biomarkers. Results: At baseline, high basal ganglia ePVS counts were associated with lower executive function scores and episodic memory scores. Moreover, baseline basal ganglia ePVS predicted worse longitudinal CDR-SB scores over the study period. Discussion: Basal ganglia ePVS burden is a promising biomarker for cSVD-related cognitive and functional decline.

Original languageEnglish
Article number123232
JournalJournal of the Neurological Sciences
Volume466
DOIs
StatePublished - Nov 15 2024

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Cerebral small vessel disease
  • Clinical dementia rating (CDR®) dementia staging instrument
  • Enlarged perivascular spaces
  • Magnetic resonance imaging
  • Neuroimaging biomarkers

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Enlarged perivascular space burden predicts declines in cognitive and functional performance'. Together they form a unique fingerprint.

Cite this