TY - JOUR
T1 - Enlarged perivascular space burden predicts declines in cognitive and functional performance
AU - Libecap, T. J.
AU - Pappas, Colleen A.
AU - Bauer, Christopher E.
AU - Zachariou, Valentinos
AU - Raslau, Flavius D.
AU - Gold, Brian T.
N1 - Publisher Copyright:
© 2024
PY - 2024/11/15
Y1 - 2024/11/15
N2 - Introduction: We evaluated the relationship between baseline enlarged perivascular space (ePVS) burden and later cognitive decline. Methods: 83 community-dwelling, older adults (aged 56–86) completed three annual cognitive assessments that included the Clinical Dementia Rating (CDR®) Dementia Staging Instrument Sum of Boxes (CDR-SB) and composite measures of executive function and episodic memory. An MRI scan at baseline was used to count ePVS in the basal ganglia and centrum semiovale. Mixed effects models were run with ePVS as the predictor variable and cognitive measures as the dependent variable. Covariates included age, sex, education, cerebral small vessel disease (cSVD) risk factors, and cSVD neuroimaging biomarkers. Results: At baseline, high basal ganglia ePVS counts were associated with lower executive function scores and episodic memory scores. Moreover, baseline basal ganglia ePVS predicted worse longitudinal CDR-SB scores over the study period. Discussion: Basal ganglia ePVS burden is a promising biomarker for cSVD-related cognitive and functional decline.
AB - Introduction: We evaluated the relationship between baseline enlarged perivascular space (ePVS) burden and later cognitive decline. Methods: 83 community-dwelling, older adults (aged 56–86) completed three annual cognitive assessments that included the Clinical Dementia Rating (CDR®) Dementia Staging Instrument Sum of Boxes (CDR-SB) and composite measures of executive function and episodic memory. An MRI scan at baseline was used to count ePVS in the basal ganglia and centrum semiovale. Mixed effects models were run with ePVS as the predictor variable and cognitive measures as the dependent variable. Covariates included age, sex, education, cerebral small vessel disease (cSVD) risk factors, and cSVD neuroimaging biomarkers. Results: At baseline, high basal ganglia ePVS counts were associated with lower executive function scores and episodic memory scores. Moreover, baseline basal ganglia ePVS predicted worse longitudinal CDR-SB scores over the study period. Discussion: Basal ganglia ePVS burden is a promising biomarker for cSVD-related cognitive and functional decline.
KW - Cerebral small vessel disease
KW - Clinical dementia rating (CDR®) dementia staging instrument
KW - Enlarged perivascular spaces
KW - Magnetic resonance imaging
KW - Neuroimaging biomarkers
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U2 - 10.1016/j.jns.2024.123232
DO - 10.1016/j.jns.2024.123232
M3 - Article
C2 - 39298972
AN - SCOPUS:85204005687
SN - 0022-510X
VL - 466
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
M1 - 123232
ER -