Environmental health research in the post-genome era: New fields, new challenges, and new opportunities

Jacquelyn J. Bower, Xianglin Shi

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The human genome sequence provides researchers with a genetic framework to eventually understand the relationships of gene-environment interactions. This wealth of information has led to the birth of several related areas of research, including proteomics, functional genomics, pharmacogenomics, and toxicogenomics. Developing techniques such as DNA/protein microarrays, small-interfering RNA (siRNA) applications, two-dimensional gel electrophoresis, and mass spectrometry in conjunction with advanced analysis software and the availability of Internet databases offers a powerful set of tools to investigate an individual's response to specific stimuli. This review summarizes these emerging scientific fields and techniques focusing specifically on their applications to the complexities of gene-environment interactions and their potential role in environmental biosecurity.

Original languageEnglish
Pages (from-to)71-94
Number of pages24
JournalJournal of Toxicology and Environmental Health - Part B: Critical Reviews
Issue number2
StatePublished - Mar 2005

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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