Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis

Pallab Pahari; Madan K. Kharel; Micah D. Shepherd; Steven G. Van Lanen; Jürgen Rohr

doi:10.1002/anie.201105882

Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis

Pallab Pahari, Madan K. Kharel, Micah D. Shepherd, Steven G. Van Lanen, Jürgen Rohr

Research output: Contribution to journal › Article › peer-review

47 Citations (SciVal)

Abstract

Teamwork: Defucogilvocarcin M (1, see scheme) was synthesized in a one-pot, enzymatic reaction from acetyl-CoA and malonyl-CoA by a combination of 15 enzymes obtained from E. coli as well as the gilvocarcin, jadomycin, and ravidomycin biosynthetic pathways. The mixture of enzymes was systematically reduced and varied to further delineate the sequence of reactions in the complex, post-polyketide steps of gilvocarcin biosynthesis.

Original language	English
Pages (from-to)	1216-1220
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/anie.201105882
State	Published - Jan 27 2012

Keywords

biosynthesis
defucogilvocarcin M
enzymes
gilvocarcins
total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry (all)

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10.1002/anie.201105882

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AU - Rohr, Jürgen

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Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis

Abstract

Keywords

ASJC Scopus subject areas

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