Teamwork: Defucogilvocarcin M (1, see scheme) was synthesized in a one-pot, enzymatic reaction from acetyl-CoA and malonyl-CoA by a combination of 15 enzymes obtained from E. coli as well as the gilvocarcin, jadomycin, and ravidomycin biosynthetic pathways. The mixture of enzymes was systematically reduced and varied to further delineate the sequence of reactions in the complex, post-polyketide steps of gilvocarcin biosynthesis.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Jan 27 2012|
- defucogilvocarcin M
- total synthesis
ASJC Scopus subject areas
- Chemistry (all)