Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic

Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr

doi:10.1021/ol1009009

Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic

Madan Kumar Kharel, Pallab Pahari, Hui Lian, Jürgen Rohr

Pharmaceutical Sciences

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33 Scopus citations

Abstract

(Figure presented) A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.

Original language	English
Pages (from-to)	2814-2817
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	12
DOIs	https://doi.org/10.1021/ol1009009
State	Published - Jun 18 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1009009

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title = "Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic",

abstract = "(Figure presented) A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.",

author = "Kharel, {Madan Kumar} and Pallab Pahari and Hui Lian and J{\"u}rgen Rohr",

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AU - Pahari, Pallab

AU - Lian, Hui

AU - Rohr, Jürgen

PY - 2010/6/18

Y1 - 2010/6/18

N2 - (Figure presented) A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.

AB - (Figure presented) A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.

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Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic

Abstract

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