Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic

Madan Kumar Kharel, Pallab Pahari, Hui Lian, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

(Figure presented) A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.

Original languageEnglish
Pages (from-to)2814-2817
Number of pages4
JournalOrganic Letters
Volume12
Issue number12
DOIs
StatePublished - Jun 18 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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