Epidemiological Aspects of Equid Herpesvirus-Associated Myeloencephalopathy (EHM) Outbreaks

Eva Klouth, Yury Zablotski, Jessica L. Petersen, Marco de Bruijn, Gittan Gröndahl, Susanne Müller, Lutz S. Goehring

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Equid Herpesvirus Myeloencephalopathy (EHM) is a multifactorial disease following an EHV-1 infection in Equidae. We investigated a total of 589 horses on 13 premises in Europe in search of risk factors for the development of EHM. We found that fever (p < 0.001), increasing age (p = 0.032), and female sex (p = 0.042) were risk factors for EHM in a logistic mixed model. Some breeds had a decreased risk to develop EHM compared to others (Shetland and Welsh ponies; p = 0.017; p = 0.031), and fewer EHV-1-vaccinated horses were affected by EHM compared to unvaccinated horses (p = 0.02). Data evaluation was complex due to high variability between outbreaks with regards to construction and environment; viral characteristics and the virus’s transmissibility were affected by operational management. This study confirms earlier suspected host-specific risk factors, and our data support the benefit of high vaccine coverage at high-traffic boarding facilities.

Original languageEnglish
Article number2576
Issue number11
StatePublished - Nov 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • age
  • boarding facility
  • breed
  • risk factor
  • sex
  • vaccination

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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