Epidural haloperidol enhances epidural morphine analgesia: Three case reports

George Colclough, John T. McLarney, Paul A. Sloan, K. Todd McCoun, Gregory L. Rose, J. S. Grider, P. Steyn

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Epidural opioids provide significant postoperative analgesia; however, their use is often limited by side effects such as nausea and pruritus, or they require the addition of epidural local anesthetics with possible side effects of motor block and hypotension. Adjuncts to epidural opioid analgesia would benefit pain management. There is evidence that epidural butyrophenones may enhance opioid analgesics and reduce side effects. The authors present the first reported use of epidural haloperidol to enhance epidural morphine analgesia in three individuals. Pharmacodynamic interactions of haloperidol, which may explain its analgesic efficacy, are summarized.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalJournal of Opioid Management
Volume4
Issue number3
DOIs
StatePublished - 2008

Keywords

  • Analgesia
  • Epidural analgesics
  • Epidural haloperidol
  • Epidural morphine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pharmacology (medical)

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