Epigenetic regulation and post-translational modifications of snai1 in cancer metastasis

Bo Dong; Yadi Wu

doi:10.3390/ijms222011062

Epigenetic regulation and post-translational modifications of snai1 in cancer metastasis

Bo Dong
, Yadi Wu

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.

Original language	English
Article number	11062
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	20
DOIs	https://doi.org/10.3390/ijms222011062
State	Published - Oct 1 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Author Contributions: All authors contributed to the manuscript content and editing for this review. B.D. wrote the manuscript. Y.W. wrote the manuscript, provided supervision and financial support. All authors have read and agreed to the published version of the manuscript.

Funders	Funder number
National Institutes of Health (NIH)	P20GM121327, CA230758
American Cancer Society-Michigan Cancer Research Fund	RSG13187
University of Kentucky Markey Comprehensive Cancer Center	P30CA177558

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

EMT
Epigenetic
Metastasis
Post-translational modifications
SNAI1

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Access to Document

10.3390/ijms222011062

Cite this

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title = "Epigenetic regulation and post-translational modifications of snai1 in cancer metastasis",

abstract = "SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.",

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author = "Bo Dong and Yadi Wu",

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doi = "10.3390/ijms222011062",

language = "English",

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AU - Dong, Bo

AU - Wu, Yadi

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N2 - SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.

AB - SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.

KW - EMT

KW - Epigenetic

KW - Metastasis

KW - Post-translational modifications

KW - SNAI1

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U2 - 10.3390/ijms222011062

DO - 10.3390/ijms222011062

M3 - Review article

C2 - 34681726

AN - SCOPUS:85117024483

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 20

M1 - 11062

ER -

Epigenetic regulation and post-translational modifications of snai1 in cancer metastasis

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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