Epigenetic regulation of LSD1 during mammary carcinogenesis

Yadi Wu; Binhua P. Zhou

doi:10.4161/21624011.2014.963426

Epigenetic regulation of LSD1 during mammary carcinogenesis

Yadi Wu, Binhua P. Zhou

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.

Original language	English
Article number	e963426
Journal	Molecular and Cellular Oncology
Volume	1
Issue number	3
DOIs	https://doi.org/10.4161/21624011.2014.963426
State	Published - Sep 15 2014

Bibliographical note

Publisher Copyright:
© 2014, © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2014, © Yadi Wu and Binhua P Zhou.

Keywords

LSD1
epigenetic
mammary carcinogenesis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/21624011.2014.963426

Cite this

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AB - Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.

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Epigenetic regulation of LSD1 during mammary carcinogenesis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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