Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.
|Journal||Molecular and Cellular Oncology|
|State||Published - Sep 15 2014|
Bibliographical noteFunding Information:
This work was supported by grants from NIH (CA125454), Mary Kay Ash Foundation, an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103527-06 (to BPZ), and American Cancer Society Research Scholar Award (RSG13187-01 to YW).
© 2014, © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2014, © Yadi Wu and Binhua P Zhou.
- mammary carcinogenesis
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research