Epigenetic regulation of LSD1 during mammary carcinogenesis

Yadi Wu; Binhua P. Zhou

doi:10.4161/21624011.2014.963426

Epigenetic regulation of LSD1 during mammary carcinogenesis

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.

Original language	English
Article number	e963426
Journal	Molecular and Cellular Oncology
Volume	1
Issue number	3
DOIs	https://doi.org/10.4161/21624011.2014.963426
State	Published - Sep 15 2014

Bibliographical note

Publisher Copyright:
© 2014, © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2014, © Yadi Wu and Binhua P Zhou.

Funding

This work was supported by grants from NIH (CA125454), Mary Kay Ash Foundation, an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103527-06 (to BPZ), and American Cancer Society Research Scholar Award (RSG13187-01 to YW).

Funders	Funder number
National Institutes of Health (NIH)	P20 GM103527-06, CA125454
American Cancer Society	RSG13187-01
National Institute of General Medical Sciences
Mary Kay Ash Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

LSD1
epigenetic
mammary carcinogenesis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

Access to Document

10.4161/21624011.2014.963426

Cite this

@article{65e3d763eedc419084cd84d78681e05b,

title = "Epigenetic regulation of LSD1 during mammary carcinogenesis",

abstract = "Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.",

keywords = "LSD1, epigenetic, mammary carcinogenesis",

author = "Yadi Wu and Zhou, \{Binhua P.\}",

note = "Publisher Copyright: {\textcopyright} 2014, {\textcopyright} 2014 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2014, {\textcopyright} Yadi Wu and Binhua P Zhou.",

year = "2014",

month = sep,

day = "15",

doi = "10.4161/21624011.2014.963426",

language = "English",

volume = "1",

number = "3",

}

TY - JOUR

T1 - Epigenetic regulation of LSD1 during mammary carcinogenesis

AU - Wu, Yadi

AU - Zhou, Binhua P.

PY - 2014/9/15

Y1 - 2014/9/15

N2 - Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.

AB - Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.

KW - LSD1

KW - epigenetic

KW - mammary carcinogenesis

UR - https://www.scopus.com/pages/publications/84991803110

UR - https://www.scopus.com/pages/publications/84991803110#tab=citedBy

U2 - 10.4161/21624011.2014.963426

DO - 10.4161/21624011.2014.963426

M3 - Article

AN - SCOPUS:84991803110

VL - 1

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e963426

ER -

Epigenetic regulation of LSD1 during mammary carcinogenesis

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this