Abstract
Modifications to DNA and core histones influence chromatin organization and expression of the genome. DNA methylation plays a significant role in the regulation of multiple biological processes that regulate behavior and caste differentiation in social insects. Histone modifications play significant roles in the regulation of development and reproduction in other insects. Genes coding for acetyltransferases, deacetylases, methyltransferases, and demethylases that modify core histones have been identified in genomes of multiple insects. Studies on the function and mechanisms of action of some of these enzymes uncovered their contribution to post-embryonic development. The results from studies on epigenetic modifiers could help in the identification of inhibitors of epigenetic modifiers that could be developed to control pests and disease vectors.
| Original language | English |
|---|---|
| Pages (from-to) | 63-69 |
| Number of pages | 7 |
| Journal | Current Opinion in Insect Science |
| Volume | 43 |
| DOIs | |
| State | Published - Feb 2021 |
Bibliographical note
Publisher Copyright:© 2020 Elsevier Inc.
Funding
Research in the Palli laboratory is supported by grants from the National Institutes of Health ( GM070559–14 and 1R21AI131427–02 ), the National Science Foundation ( Industry/University Cooperative Research Centers , the Center for Arthropod Management Technologies under grant IIP-1821936 ), and the USDA/NIFA (under Hatch Project 2351177000 and Agriculture and Food Research Initiative Competitive Grant 2019-67013-29351 ).
| Funders | Funder number |
|---|---|
| USDA NIFA | 2019-67013-29351, 2351177000 |
| National Science Foundation Arctic Social Science Program | |
| National Institutes of Health (NIH) | 1R21AI131427–02 |
| National Institute of General Medical Sciences COBRE | R01GM070559 |
| Center for Arthropod Management Technologies | IIP-1821936 |
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Insect Science