Epigenetic regulation of prostate cancer

Ruixin Wang, Xiaoqi Liu

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Prostate cancer is (PCa) the second leading cause of cancer death in males in the United State, with 174,650 new cases and 31,620 deaths estimated in 2019. It has been documented that epigenetic deregulation such as histone modification and DNA methylation contributes to PCa initiation and progression. EZH2 (enhancer of zeste homolog 2), the catalytic subunit of the Polycomb Repressive Complex (PRC2) responsible for H3K27me3 and gene repression, has been identified as a promising target in PCa. In addition, overexpression of other epigenetic regulators such as DNA methyltransferases (DNMT) is also observed in PCa. These epigenetic regulators undergo extensive post-translational modifications, in particular, phosphorylation. AKT, CDKs, PLK1, PKA, ATR and DNA-PK are the established kinases responsible for phosphorylation of various epigenetic regulators.

Original languageEnglish
Pages (from-to)606-613
Number of pages8
JournalGenes and Diseases
Issue number4
StatePublished - Dec 2020

Bibliographical note

Publisher Copyright:
© 2019 Chongqing Medical University


  • DNMT
  • EZH2
  • Epigenetics
  • HDAC
  • Phosphorylation
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology


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