Prostate cancer (PCa) is the most commonly diagnosed malignancy among men, and the progression of this disease results in fewer treatment options available to clinical patients. It highlights the vital necessity for discovering novel therapeutic approaches and expanding the current understanding of molecular mechanisms. Epigenetic alternations such as DNA methylation models and histone modifications have been associated as key drivers in the development and advancement of PCa. Several studies have been conducted and demonstrated that targeting these epigenetic enzymes or regulatory proteins has been strongly associated with the regulation of cancer cell growth. Due to the success rate of these therapeutic routes in pre-clinical settings, many drugs have now advanced to clinical testing, where efficacy will be measured. This review will discuss the role of epigenetic modifications in PCa development and its function in the progression of the disease to resistant forms and introduce therapeutic strategies that have demonstrated successful results as PCa treatment.
Bibliographical noteFunding Information:
The work was supported by NIH grants R01 CA157429 (Liu X), R01 CA192894 (Liu X), R01 CA196835 (Liu X), and R01 CA196634 (Liu X). The work was also supported by the DTCB internal fellowship (Liu J).
© The Author(s) 2021.
- prostate cancer
- prostate cancer treatment
ASJC Scopus subject areas