EPR-spin trapping kinetic studies of superoxide radicals produced by pmotosensitized hypocrellin A, a photodynamic therapeutic agent

Lun Yi Zang; Xianglin Shi; Hara P. Misra

EPR-spin trapping kinetic studies of superoxide radicals produced by pmotosensitized hypocrellin A, a photodynamic therapeutic agent

Lun Yi Zang, Xianglin Shi, Hara P. Misra

Toxicology and Cancer Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10^-3 s^-1. The first-order rate constant (k₁) and the half-life time (t_0.5) for DMPO-O₂^- decay were 2.86 x 10^-3 s^-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.

Original language	English
Pages (from-to)	685-691
Number of pages	7
Journal	Biochemistry and Molecular Biology International
Volume	38
Issue number	4
State	Published - 1996

Keywords

EPR
Hypocrellin A
Kinetics
Spin trapping
Superoxide radicals

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

Cite this

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title = "EPR-spin trapping kinetic studies of superoxide radicals produced by pmotosensitized hypocrellin A, a photodynamic therapeutic agent",

abstract = "Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10-3 s-1. The first-order rate constant (k1) and the half-life time (t0.5) for DMPO-O2- decay were 2.86 x 10-3 s-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.",

keywords = "EPR, Hypocrellin A, Kinetics, Spin trapping, Superoxide radicals",

author = "Zang, {Lun Yi} and Xianglin Shi and Misra, {Hara P.}",

year = "1996",

language = "English",

volume = "38",

pages = "685--691",

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T1 - EPR-spin trapping kinetic studies of superoxide radicals produced by pmotosensitized hypocrellin A, a photodynamic therapeutic agent

AU - Zang, Lun Yi

AU - Shi, Xianglin

AU - Misra, Hara P.

PY - 1996

Y1 - 1996

N2 - Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10-3 s-1. The first-order rate constant (k1) and the half-life time (t0.5) for DMPO-O2- decay were 2.86 x 10-3 s-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.

AB - Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10-3 s-1. The first-order rate constant (k1) and the half-life time (t0.5) for DMPO-O2- decay were 2.86 x 10-3 s-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.

KW - EPR

KW - Hypocrellin A

KW - Kinetics

KW - Spin trapping

KW - Superoxide radicals

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M3 - Article

C2 - 8728097

AN - SCOPUS:0029775052

SN - 1039-9712

VL - 38

SP - 685

EP - 691

JO - Biochemistry and Molecular Biology International

JF - Biochemistry and Molecular Biology International

IS - 4

ER -

EPR-spin trapping kinetic studies of superoxide radicals produced by pmotosensitized hypocrellin A, a photodynamic therapeutic agent

Abstract

Keywords

ASJC Scopus subject areas

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