Abstract
Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10-3 s-1. The first-order rate constant (k1) and the half-life time (t0.5) for DMPO-O2- decay were 2.86 x 10-3 s-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.
Original language | English |
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Pages (from-to) | 685-691 |
Number of pages | 7 |
Journal | Biochemistry and Molecular Biology International |
Volume | 38 |
Issue number | 4 |
State | Published - 1996 |
Keywords
- EPR
- Hypocrellin A
- Kinetics
- Spin trapping
- Superoxide radicals
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics