EPR-spin trapping kinetic studies of superoxide radicals produced by pmotosensitized hypocrellin A, a photodynamic therapeutic agent

Lun Yi Zang, Xianglin Shi, Hara P. Misra

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Kinetics of superoxide radicals generation by a photodynamic therapeutic agent, Hypocrellin A has been studied by EPR-spin trapping technique. The rate constant (k(g)) for superoxide radicals generation by Hypocrellin A was found to be 5.0 x 10-3 s-1. The first-order rate constant (k1) and the half-life time (t0.5) for DMPO-O2- decay were 2.86 x 10-3 s-1 and 242.3 s, respectively. It appears that oxyradicals, generated during the photodynamic process, may be associated with the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.

Original languageEnglish
Pages (from-to)685-691
Number of pages7
JournalBiochemistry and Molecular Biology International
Volume38
Issue number4
StatePublished - 1996

Keywords

  • EPR
  • Hypocrellin A
  • Kinetics
  • Spin trapping
  • Superoxide radicals

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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