TY - JOUR
T1 - Equine Breeding-Induced Endometritis
T2 - A Review
AU - Woodward, Elizabeth M.
AU - Troedsson, Mats H.
PY - 2013/9
Y1 - 2013/9
N2 - Although endometritis is a normal occurrence after breeding, persistent inflammation threatens the success of the pregnancy. Persistent endometritis has been cited as a leading reproductive health concern in the mare. A variety of factors contribute to susceptibility to persistent breeding induced endometritis, including age, endometrial quality, and reproductive history. Seminal plasma mediates the immune response to breeding, as it has protective properties for viable spermatozoa, while aiding in the recognition and targeting of dead spermatozoa by the mare's immune response. Although the adaptive immune response has been implicated in the response to breeding, the innate immune response along with mechanical clearance are the primary mechanisms suggested to act to clear endometritis. Mares susceptible to persistent breeding induced endometritis have an altered innate immune response after breeding compared to resistant mares. There are multiple tools and strategies utilized for the diagnosis and treatment of persistent endometritis. This review of the literature summarizes research investigating the causes, pathogenesis, and treatments of persistent breeding induced endometritis.
AB - Although endometritis is a normal occurrence after breeding, persistent inflammation threatens the success of the pregnancy. Persistent endometritis has been cited as a leading reproductive health concern in the mare. A variety of factors contribute to susceptibility to persistent breeding induced endometritis, including age, endometrial quality, and reproductive history. Seminal plasma mediates the immune response to breeding, as it has protective properties for viable spermatozoa, while aiding in the recognition and targeting of dead spermatozoa by the mare's immune response. Although the adaptive immune response has been implicated in the response to breeding, the innate immune response along with mechanical clearance are the primary mechanisms suggested to act to clear endometritis. Mares susceptible to persistent breeding induced endometritis have an altered innate immune response after breeding compared to resistant mares. There are multiple tools and strategies utilized for the diagnosis and treatment of persistent endometritis. This review of the literature summarizes research investigating the causes, pathogenesis, and treatments of persistent breeding induced endometritis.
KW - Endometritis
KW - Endometrium
KW - Equine
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=84883240437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883240437&partnerID=8YFLogxK
U2 - 10.1016/j.jevs.2012.11.010
DO - 10.1016/j.jevs.2012.11.010
M3 - Review article
AN - SCOPUS:84883240437
SN - 0737-0806
VL - 33
SP - 673
EP - 682
JO - Journal of Equine Veterinary Science
JF - Journal of Equine Veterinary Science
IS - 9
ER -