Equine Protozoal Myeloencephalitis

Martin Furr, Daniel K. Howe

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Equine protozoal myeloencephalitis (EPM) is a commonly diagnosed neurologic condition of the horse that was originally described in 1964 by J. Rooney's "segmental myelitis". Consistent with the geographic range of the opossum definitive hosts, EPM caused by S. neurona is a disease of North, Central, and South America. Most horses with a diagnosis of EPM outside this region appear to have spent some time in the endemic area. Gross lesions in the central nervous system (CNS) of EPM horses are sometimes inapparent. When present, lesions are random and multifocal and are more commonly seen in the spinal cord but can occur in the brain or brainstem. Once the organism has infected the nervous system, it leads to localized inflammation with clinical neurologic abnormalities that are dependent upon the anatomic site of the infection in the CNS. The use of antiprotozoal compounds is the cornerstone of treatment for EPM.

Original languageEnglish
Title of host publicationEquine Neurology
Subtitle of host publicationSecond Edition
Number of pages21
ISBN (Electronic)9781118993712
StatePublished - Aug 3 2015

Bibliographical note

Publisher Copyright:
© 2015 John Wiley & Sons, Inc.


  • Brainstem
  • Central nervous system (CNS)
  • Equine protozoal myeloencephalitis (EPM)
  • Horse
  • Lesions
  • S. neurona
  • Spinal cord
  • segmental myelitis

ASJC Scopus subject areas

  • General Veterinary


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