Abstract
There is limited information on access and outcomes of patients living with human immunodeficiency virus (PLWH) who have undergone pancreas transplantation. We conducted a retrospective cohort study analyzing data from the United Network for Organ Sharing from July 1, 2001, to June 30, 2021. Recipients of pancreas transplant were stratified by HIV serostatus. Graft and patient survival were analyzed using Kaplan-Meier product limit estimates. Multivariable Cox proportional hazard models were generated to identify factors associated with increased mortality or graft loss. Fifty PLWH and 16 380 patients without HIV underwent pancreas (with kidney) transplantation. PLWH were more often male (P < .001), Black/African American (P = .009), and on Medicare (P = .004). There were no significant differences in waiting time (P = .159) or proportion of patients treated for rejection within 1 year of transplant (P = .189) between groups. There were no differences in pancreas graft survival (P = .964) and overall patient survival (P = .250) between the cohorts. Dialysis status was negatively associated with graft survival. Although PLWH were more likely to represent a historically marginalized population, their outcomes after pancreas transplant were similar to their counterparts without HIV.
| Original language | English |
|---|---|
| Pages (from-to) | 2267-2276 |
| Number of pages | 10 |
| Journal | American Journal of Transplantation |
| Volume | 25 |
| Issue number | 10 |
| DOIs |
|
| State | Published - Oct 2025 |
Bibliographical note
Publisher Copyright:© 2025
Funding
The Professional Student Mentored Research Fellowship (PSMRF) Project is supported by the National Center for Advancing Translational Sciences (UL1TR001998), UK HealthCare, and the University of Kentucky College of Medicine. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The work was also supported in part by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The Professional Student Mentored Research Fellowship Project is supported by the National Center for Advancing Translational Sciences through Grant UL1TR001998, UK HealthCare and the University of Kentucky College of Medicine . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health . The work was also supported in part by Health Resources and Services Administration contract 234-2005-370011C. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
| Funders | Funder number |
|---|---|
| University of Kentucky | |
| National Institutes of Health (NIH) | |
| US Government or NYU | |
| U.S. Department of Health and Human Services | |
| National Center for Advancing Translational Sciences (NCATS) | UL1TR001998 |
| Health Resources and Services Administration | 234-2005-370011C |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- HIV
- kidney
- outcomes
- pancreas
- transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation
- Pharmacology (medical)
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