Erythrocyte membrane alterations in Huntington disease: Effects of γ-aminobutyric acid

D. A. Butterfield, M. L. Braden, W. R. Markesbery

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The interaction of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) with erythrocyte membranes from patients with Huntington disease and normal controls has been studied by electron spin resonance. GABA affects the physical state of erythrocyte membrane proteins in control and Huntington disease differently. In addition, after exposure of spin-labeled Huntington disease erythrocyte membranes to 0.1 mM GABA, the relevant electron spin resonance parameters reflecting the physical state of membrane proteins are indistinguishable from those of untreated control membranes. These findings support the concept that this disease is associated with a generalized membrane defect.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalJournal of Supramolecular and Cellular Biochemistry
Issue number1
StatePublished - 1979

ASJC Scopus subject areas

  • Biochemistry


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