Abstract
Electron spin resonance (ESR) measurements show that grinding of quartz particles in air produces silicon-based (Si· and SiO· radicals which decay with aging in air. ESR spin trapping measurements provide evidence for the generation of hydroxyl and possibly superoxide radicals from a suspension of fresh quartz particles. The hydroxyl radical generation potential of the fresh quartz particles decreases on storing in ambient air and on the addition of catalase, superoxide dismutase, desferroxamine. or DMSO. Silica-induced lipid peroxidation also decreases on storing the fresh particles in ambient air. These findings suggest that oxygenated radicals play a role in the biochemical mechanism of pneumoconiosis in general and acute silicosis in particular.
| Original language | English |
|---|---|
| Pages (from-to) | 259-266 |
| Number of pages | 8 |
| Journal | Free Radical Research |
| Volume | 9 |
| Issue number | 3-6 |
| DOIs | |
| State | Published - 1990 |
Bibliographical note
Funding Information:This research has been supported by the Department of the Interior's Mineral Institute Program administered by the Bureau of Mine through the Generic Technology Center for Respirable Dust under grant GI 135142.
Funding
This research has been supported by the Department of the Interior's Mineral Institute Program administered by the Bureau of Mine through the Generic Technology Center for Respirable Dust under grant GI 135142.
| Funders | Funder number |
|---|---|
| Bureau of Mine | |
| Generic Mineral Technology Center for Respirable Dust | GI 135142 |
| U.S. Department of the Interior |
Keywords
- Cytotoxicity
- ESR
- Free radicals
- Quartz
- Spin trapping
ASJC Scopus subject areas
- Biochemistry