Essential Roles of Peroxiredoxin IV in Inflammation and Cancer

Pratik Thapa, Na Ding, Yanning Hao, Aziza Alshahrani, Hong Jiang, Qiou Wei

Research output: Contribution to journalReview articlepeer-review

Abstract

Peroxiredoxin IV (Prx4) is a 2-Cysteine peroxidase with ubiquitous expression in human tissues. Prx4 scavenges hydrogen peroxide and participates in oxidative protein folding in the endoplasmic reticulum. In addition, Prx4 is secreted outside the cell. Prx4 is upregulated in several cancers and is a potential therapeutic target. We have summarized historical and recent advances in the structure, function and biological roles of Prx4, focusing on inflammatory diseases and cancer. Oxidative stress is known to activate pro-inflammatory pathways. Chronic inflammation is a risk factor for cancer development. Hence, redox enzymes such as Prx4 are important players in the crosstalk between inflammation and cancer. Understanding molecular mechanisms of regulation of Prx4 expression and associated signaling pathways in normal physiological and disease conditions should reveal new therapeutic strategies. Thus, although Prx4 is a promising therapeutic target for inflammatory diseases and cancer, further research needs to be conducted to bridge the gap to clinical application.

Original languageEnglish
Article number6513
JournalMolecules
Volume27
Issue number19
DOIs
StatePublished - Oct 2022

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (NCI R01CA222596, NIEHS T32ES07266), Department of Defense (grant number W81XWH-16-1-0203), American Cancer Society (grant number RSG-16-213-01-TBE) and the Kentucky Lung Cancer Research Program (KLCRP2016). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other funding agencies.

Publisher Copyright:
© 2022 by the authors.

Keywords

  • cancer
  • hydrogen peroxide
  • inflammation
  • oxidative protein folding
  • peroxiredoxin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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