TY - JOUR
T1 - Essramycin
T2 - A first triazolopyrimidine antibiotic isolated from nature
AU - El-Gendy, Mervat M.A.
AU - Shaaban, Mohamed
AU - Shaaban, Khaled A.
AU - El-Bondkly, Ahmed M.
AU - Laatsch, Hartmut
PY - 2008/3
Y1 - 2008/3
N2 - In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 μg/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.
AB - In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 μg/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.
KW - Essramycin
KW - Marine Streptomyces sp.
KW - Triazolopyrimidine
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U2 - 10.1038/ja.2008.124
DO - 10.1038/ja.2008.124
M3 - Article
C2 - 18503193
AN - SCOPUS:54049118862
SN - 0021-8820
VL - 61
SP - 149
EP - 157
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 3
ER -
