Essramycin: A first triazolopyrimidine antibiotic isolated from nature

Mervat M.A. El-Gendy, Mohamed Shaaban, Khaled A. Shaaban, Ahmed M. El-Bondkly, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

152 Scopus citations


In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 μg/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalJournal of Antibiotics
Issue number3
StatePublished - Mar 2008


  • Essramycin
  • Marine Streptomyces sp.
  • Triazolopyrimidine

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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