Establishing EDI for a Clinical Trial of a Treatment for Chikungunya

Cynthia Dickerson; Mark Ensor; Robert A. Lodder

doi:10.1007/978-3-319-93701-4_61

Establishing EDI for a Clinical Trial of a Treatment for Chikungunya

Cynthia Dickerson, Mark Ensor, Robert A. Lodder

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Ellagic acid (EA) is a polyphenolic compound with antiviral activity against chikungunya, a rapidly spreading new tropical disease transmitted to humans by mosquitoes and now affecting millions worldwide. The most common symptoms of chikungunya virus infection are fever and joint pain. Other manifestations of infection can include encephalitis and an arthritic joint swelling with pain that may persist for months or years after the initial infection. The disease has recently spread to the U.S.A., with locally-transmitted cases of chikungunya virus reported in Florida. There is no approved vaccine to prevent or medicine to treat chikungunya virus infections. In this study, the Estimated Daily Intake (EDI) of EA from the food supply established using the National Health and Nutrition Examination Survey (NHANES) is used to set a maximum dose of an EA formulation for a high priority clinical trial.

Original language	English
Title of host publication	Computational Science – ICCS 2018 - 18th International Conference, Proceedings
Editors	Valeria V. Krzhizhanovskaya, Michael Harold Lees, Peter M. Sloot, Jack Dongarra, Yong Shi, Yingjie Tian, Haohuan Fu
Pages	773-782
Number of pages	10
DOIs	https://doi.org/10.1007/978-3-319-93701-4_61
State	Published - 2018
Event	18th International Conference on Computational Science, ICCS 2018 - Wuxi, China Duration: Jun 11 2018 → Jun 13 2018

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	10861 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	18th International Conference on Computational Science, ICCS 2018
Country/Territory	China
City	Wuxi
Period	6/11/18 → 6/13/18

Bibliographical note

Publisher Copyright:
© Springer International Publishing AG, part of Springer Nature 2018.

Keywords

Drug development
NHANES
Tropical disease

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-93701-4_61

Cite this

Dickerson, C., Ensor, M., & Lodder, R. A. (2018). Establishing EDI for a Clinical Trial of a Treatment for Chikungunya. In V. V. Krzhizhanovskaya, M. H. Lees, P. M. Sloot, J. Dongarra, Y. Shi, Y. Tian, & H. Fu (Eds.), Computational Science – ICCS 2018 - 18th International Conference, Proceedings (pp. 773-782). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10861 LNCS). https://doi.org/10.1007/978-3-319-93701-4_61

Dickerson, Cynthia ; Ensor, Mark ; Lodder, Robert A. / Establishing EDI for a Clinical Trial of a Treatment for Chikungunya. Computational Science – ICCS 2018 - 18th International Conference, Proceedings. editor / Valeria V. Krzhizhanovskaya ; Michael Harold Lees ; Peter M. Sloot ; Jack Dongarra ; Yong Shi ; Yingjie Tian ; Haohuan Fu. 2018. pp. 773-782 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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abstract = "Ellagic acid (EA) is a polyphenolic compound with antiviral activity against chikungunya, a rapidly spreading new tropical disease transmitted to humans by mosquitoes and now affecting millions worldwide. The most common symptoms of chikungunya virus infection are fever and joint pain. Other manifestations of infection can include encephalitis and an arthritic joint swelling with pain that may persist for months or years after the initial infection. The disease has recently spread to the U.S.A., with locally-transmitted cases of chikungunya virus reported in Florida. There is no approved vaccine to prevent or medicine to treat chikungunya virus infections. In this study, the Estimated Daily Intake (EDI) of EA from the food supply established using the National Health and Nutrition Examination Survey (NHANES) is used to set a maximum dose of an EA formulation for a high priority clinical trial.",

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author = "Cynthia Dickerson and Mark Ensor and Lodder, {Robert A.}",

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Dickerson, C, Ensor, M & Lodder, RA 2018, Establishing EDI for a Clinical Trial of a Treatment for Chikungunya. in VV Krzhizhanovskaya, MH Lees, PM Sloot, J Dongarra, Y Shi, Y Tian & H Fu (eds), Computational Science – ICCS 2018 - 18th International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 10861 LNCS, pp. 773-782, 18th International Conference on Computational Science, ICCS 2018, Wuxi, China, 6/11/18. https://doi.org/10.1007/978-3-319-93701-4_61

Establishing EDI for a Clinical Trial of a Treatment for Chikungunya. / Dickerson, Cynthia; Ensor, Mark; Lodder, Robert A.
Computational Science – ICCS 2018 - 18th International Conference, Proceedings. ed. / Valeria V. Krzhizhanovskaya; Michael Harold Lees; Peter M. Sloot; Jack Dongarra; Yong Shi; Yingjie Tian; Haohuan Fu. 2018. p. 773-782 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10861 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ensor, Mark

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N1 - Publisher Copyright: © Springer International Publishing AG, part of Springer Nature 2018.

PY - 2018

Y1 - 2018

N2 - Ellagic acid (EA) is a polyphenolic compound with antiviral activity against chikungunya, a rapidly spreading new tropical disease transmitted to humans by mosquitoes and now affecting millions worldwide. The most common symptoms of chikungunya virus infection are fever and joint pain. Other manifestations of infection can include encephalitis and an arthritic joint swelling with pain that may persist for months or years after the initial infection. The disease has recently spread to the U.S.A., with locally-transmitted cases of chikungunya virus reported in Florida. There is no approved vaccine to prevent or medicine to treat chikungunya virus infections. In this study, the Estimated Daily Intake (EDI) of EA from the food supply established using the National Health and Nutrition Examination Survey (NHANES) is used to set a maximum dose of an EA formulation for a high priority clinical trial.

AB - Ellagic acid (EA) is a polyphenolic compound with antiviral activity against chikungunya, a rapidly spreading new tropical disease transmitted to humans by mosquitoes and now affecting millions worldwide. The most common symptoms of chikungunya virus infection are fever and joint pain. Other manifestations of infection can include encephalitis and an arthritic joint swelling with pain that may persist for months or years after the initial infection. The disease has recently spread to the U.S.A., with locally-transmitted cases of chikungunya virus reported in Florida. There is no approved vaccine to prevent or medicine to treat chikungunya virus infections. In this study, the Estimated Daily Intake (EDI) of EA from the food supply established using the National Health and Nutrition Examination Survey (NHANES) is used to set a maximum dose of an EA formulation for a high priority clinical trial.

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A2 - Tian, Yingjie

A2 - Fu, Haohuan

T2 - 18th International Conference on Computational Science, ICCS 2018

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ER -

Dickerson C, Ensor M, Lodder RA. Establishing EDI for a Clinical Trial of a Treatment for Chikungunya. In Krzhizhanovskaya VV, Lees MH, Sloot PM, Dongarra J, Shi Y, Tian Y, Fu H, editors, Computational Science – ICCS 2018 - 18th International Conference, Proceedings. 2018. p. 773-782. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-319-93701-4_61

Establishing EDI for a Clinical Trial of a Treatment for Chikungunya

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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