Abstract
Increased concentrations of β2-microglobulin in cerebrospinal fluid have been used to detect central nervous system involvement with metastatic cancer and with neurological complications of AIDS. However, no adequate reference interval study has been reported for β2-microglobulin in cerebrospinal fluid. We established a reference interval with both the Abbott IMx microparticle enzymelinked immunoassay (EIA) (0.6-2.0 mg/L) and the Pharmacia β2-micro EIA 96 method (0.8-2.2 mg/L) for β2 - microglobulin in cerebrospinal fluid. The two methods correlate well, with the latter method giving slightly higher values. β2-Microglobulin increases with age in adults by about 0.1 mg/L every 7.5 years, with no significant difference between genders.
Original language | English |
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Pages (from-to) | 104-107 |
Number of pages | 4 |
Journal | Clinical Chemistry |
Volume | 37 |
Issue number | 1 |
State | Published - 1991 |
Keywords
- Acquired immune deficiency syndrome
- Age-related effects
- Cancer
- Central nervous system
- Enzyme immunoassay
- HIV
ASJC Scopus subject areas
- General Medicine