Establishment of a reference interval for β2-microglobulin in cerebrospinal fluid with use of two commercial assays

Charles T. Lutz, Steven H. Cornell, James A. Goeken

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Increased concentrations of β2-microglobulin in cerebrospinal fluid have been used to detect central nervous system involvement with metastatic cancer and with neurological complications of AIDS. However, no adequate reference interval study has been reported for β2-microglobulin in cerebrospinal fluid. We established a reference interval with both the Abbott IMx microparticle enzymelinked immunoassay (EIA) (0.6-2.0 mg/L) and the Pharmacia β2-micro EIA 96 method (0.8-2.2 mg/L) for β2 - microglobulin in cerebrospinal fluid. The two methods correlate well, with the latter method giving slightly higher values. β2-Microglobulin increases with age in adults by about 0.1 mg/L every 7.5 years, with no significant difference between genders.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalClinical Chemistry
Volume37
Issue number1
StatePublished - 1991

Keywords

  • Acquired immune deficiency syndrome
  • Age-related effects
  • Cancer
  • Central nervous system
  • Enzyme immunoassay
  • HIV

ASJC Scopus subject areas

  • General Medicine

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