Estradiol: A protective and trophic factor in the brain

D. B. Dubal, M. E. Wilson, P. M. Wise

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


In recent years our appreciation that estradiol is truly a pleiotropic hormone has grown dramatically. We will review the findings that suggest that estrogens may exert important non-reproductive actions on the brain. These studies provide important insights into the clinical effects of estrogen replacement therapy on age- and disease-related processes in the brain. We will also discuss the multiple cellular and molecular mechanisms that may underlie estradiol's neurotrophic and neuroprotective effects.

Original languageEnglish
Pages (from-to)265-274
Number of pages10
JournalJournal of Alzheimer's Disease
Issue number4-5
StatePublished - 1999

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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