Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

P. M. Wise, D. B. Dubal, M. E. Wilson, S. W. Rau

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

Original languageEnglish
Pages (from-to)401-410
Number of pages10
JournalJournal of Neurocytology
Issue number5-6
StatePublished - 2000

Bibliographical note

Funding Information:
Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience (all)
  • Histology
  • Cell Biology


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