Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

P. M. Wise; D. B. Dubal; M. E. Wilson; S. W. Rau

doi:10.1023/A:1007169408561

Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

P. M. Wise
, D. B. Dubal
, M. E. Wilson
, S. W. Rau

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

Original language	English
Pages (from-to)	401-410
Number of pages	10
Journal	Journal of Neurocytology
Volume	29
Issue number	5-6
DOIs	https://doi.org/10.1023/A:1007169408561
State	Published - 2000

Bibliographical note

Funding Information:
Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

Funding

Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

Funders	Funder number
DBD
Glenn Foundation/American Federation for Aging Research
National Institutes of Health (NIH)	AG00242, AG02224
National Institute on Aging	F32AG005818
University of Kentucky

ASJC Scopus subject areas

Anatomy
General Neuroscience
Histology
Cell Biology

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abstract = "Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.",

author = "Wise, \{P. M.\} and Dubal, \{D. B.\} and Wilson, \{M. E.\} and Rau, \{S. W.\}",

note = "Funding Information: Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice Chancellor{\~O}s Research Funds (PMW).",

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AU - Dubal, D. B.

AU - Wilson, M. E.

AU - Rau, S. W.

N1 - Funding Information: Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

PY - 2000

Y1 - 2000

N2 - Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

AB - Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

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JF - Journal of Neurocytology

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ER -

Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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