Estrogen regulation of adipose tissue lipoprotein lipase - Possible mechanism of body fat distribution

T. M. Price, S. N. O'Brien, B. H. Welter, R. George, J. Anandjiwala, M. Kilgore

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


OBJECTIVE: The purpose of this study was to evaluate the regulation of lipoprotein lipase activity, protein mass, and messenger ribonucleic acid by estradiol. STUDY DESIGN: Premenopausal women not taking exogenous sex steroids had transdermal 17β-estradiol and placebo patches placed in the gluteal region during the early follicular phase of the menstrual cycle. Adipose biopsies were performed from beneath the patches. Adipose tissue lipoprotein lipase activity was determined by a radiometric assay, protein mass was determined by enzyme-linked immunosorbent assay, and messenger ribonucleic acid level was determined by Northern analysis. Comparisons between the treated and placebo sides were analyzed by nonparametric statistics. RESULTS: Adipose tissue from beneath the 17β-estradiol patch had significantly decreased lipoprotein lipase activity and extracellular protein mass than did adipose tissue from beneath the placebo patch. There was no difference in lipoprotein lipase messenger ribonucleic acid levels. CONCLUSION: Estrogen decreases lipoprotein lipase activity by a posttranscriptional modification of protein levels. A hypothesis of sex steroid regulation of body fat distribution is proposed.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1 I
StatePublished - 1998

Bibliographical note

Funding Information:
Supported in part by the National Heart Foundation, a program of the American Health Assistance Foundation.

Copyright 2017 Elsevier B.V., All rights reserved.


  • Body fat distribution
  • Estrogen
  • Lipoprotein lipase

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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