Ethanol induces a dose-dependent conditioned place preference and conditioned place aversion in Japanese quail.

Shannon E. Eaton, Svetlana Dzhala, Layne E. Robinson, Mia E. Radevski, Chana K. Akins

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The conditioned place preference (CPP) paradigm is commonly used to investigate the motivational properties of drugs of abuse. Cues in the environment may become paired with these motivational properties and later result in drug seeking. Because many of these alcohol-paired cues are visual, Japanese quail may be a beneficial model to examine visual cue-induced alcohol seeking behavior. The aim of the present study was to examine the motivational properties of ethanol using a visual CPP model. During CPP, quail were given an initial preference test to determine their initially preferred chamber, during which time they could explore the entire chamber for 15 min. Following the initial preference test, quail were gavaged with their assigned treatment (water or 0.75 or 2.0 g/kg of ethanol) and were confined to their initially least preferred chamber every other conditioning day for 30 min. On alternate days, they were gavaged with water and confined to the preferred chamber for 30 min. After the 8th day of conditioning, a final preference test was given. Locomotor activity was also measured during conditioning. The findings indicated that quail that received the 0.75 g/kg ethanol developed a place preference to the ethanol-paired chamber, and that quail treated with 2 g/kg ethanol developed a place aversion to the ethanol-paired chamber. Additionally, locomotor activity was reduced in quail that received the high dose of ethanol. The findings suggest that both the rewarding and aversive properties of ethanol may be observable in this visual cue CPP model.

Original languageEnglish
JournalExperimental and Clinical Psychopharmacology
DOIs
StateAccepted/In press - 2022

Bibliographical note

Funding Information:
The current research was supported by a Super Star Grant from the University of Kentucky’s Substance Use Priority Research Area (SUPRA) awarded to SEE and SD and a training grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, T32AA027488) awarded to SEE. All authors contributed to the manuscript in a significant way and all authors have read and approved the final manuscript. None of the authors have a conflict of interest, including financial, personal, or other relationships with other organizations or pharmaceutical/ biomedical companies that may inappropriately impact or influence the research and interpretations of the findings. Shannon E. Eaton played lead role in conceptualization, formal analysis, funding acquisition, investigation and methodology, and equal role in supervision and writing of original draft. Svetlana Dzhala played lead role in funding acquisition and supporting role in data curation and writing of original draft. Layne E. Robinson played supporting role in data curation and writing of original draft. Mia E. Radevski played supporting role in data curation, writing of original draft and data analysis. Chana K. Akins played lead role in conceptualization, formal analysis, funding acquisition, investigation, methodology, project administration, supervision, writing of original draft and writing of review and editing.

Publisher Copyright:
© 2022 American Psychological Association

Keywords

  • Conditioned place aversion
  • Conditioned place preference
  • Ethanol
  • Japanese quail
  • Visual cues

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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