Ethanol Induces a Dose-Dependent Conditioned Place Preference and Conditioned Place Aversion in Japanese Quail

Shannon E. Eaton, Svetlana Dzhala, Layne E. Robinson, Mia E. Radevski, Chana K. Akins

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The conditioned place preference (CPP) paradigm is commonly used to investigate the motivational properties of drugs of abuse. Cues in the environment may become paired with these motivational properties and later result in drug seeking. Because many of these alcohol-paired cues are visual, Japanese quail may be a beneficial model to examine visual cue-induced alcohol seeking behavior. The aim of the present study was to examine the motivational properties of ethanol using a visual CPP model. During CPP, quail were given an initial preference test to determine their initially preferred chamber, during which time they could explore the entire chamber for 15 min. Following the initial preference test, quail were gavaged with their assigned treatment (water or 0.75 or 2.0 g/kg of ethanol) and were confined to their initially least preferred chamber every other conditioning day for 30 min. On alternate days, they were gavaged with water and confined to the preferred chamber for 30 min. After the 8th day of conditioning, a final preference test was given. Locomotor activity was also measured during conditioning. The findings indicated that quail that received the 0.75 g/kg ethanol developed a place preference to the ethanol-paired chamber, and that quail treated with 2 g/kg ethanol developed a place aversion to the ethanol-paired chamber. Additionally, locomotor activity was reduced in quail that received the high dose of ethanol.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalExperimental and Clinical Psychopharmacology
Issue number1
StatePublished - Jan 27 2022

Bibliographical note

Funding Information:
The current research was supported by a Super Star Grant from the University of Kentucky’s Substance Use Priority Research Area (SUPRA) awarded to SEE and SD and a training grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, T32AA027488) awarded to SEE

Publisher Copyright:
© 2022 American Psychological Association


  • Japanese quail
  • conditioned place aversion
  • conditioned place preference
  • ethanol
  • visual cues

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology


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