Evaluating autonomy, beneficence, and justice with substance-using populations: Implications for clinical research participation

Justin C. Strickland, William W. Stoops

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Narrow inclusion criteria regarding substance use are commonplace in clinical research. This is due, in part, to assumptions about capacity to make "rational" decisions regarding participation by these populations. This study evaluated decision-making and perceptions surrounding each of the Belmont principles among individuals with cocaine use histories, cigarette smokers without illicit substance use histories, and controls without cigarette or illicit substance use histories. Cocaine (n = 124), cigarette (n = 128), and control (n = 145) groups were recruited using Amazon's Mechanical Turk. Participants completed measures evaluating research participation after reading two hypothetical study vignettes varying in risk. Assays assessed capacity to consent, perceived research burden, and endorsement of research participation by various populations. Individuals reporting cocaine use showed a reduced capacity to consent compared to controls, but this effect was small and largely explained by sociodemographic differences (e.g., race) rather than substance use history. Perceived research burden in the cigarette group was lower than in the cocaine group, but this difference was of a small to medium effect size. All groups reported substantively lower endorsement of research participation by individuals with illicit substance use histories relative to healthy adults, with less support indicated by control and cigarette groups compared to the cocaine group. Few differences were observed by substance use history regarding perceptions of and decision-making surrounding research participation. These data highlight the need for the continued study of evidence-based ethics and support more widespread acceptance of research participation by individuals with substance use histories in clinical research.

Original languageEnglish
Pages (from-to)552-563
Number of pages12
JournalPsychology of Addictive Behaviors
Volume32
Issue number5
DOIs
StatePublished - Aug 2018

Bibliographical note

Publisher Copyright:
© 2018 American Psychological Association.

Funding

This research was supported by an American Psychological Association Division 50 (Society of Addiction Psychology) Student Research Grant to Justin C. Strickland, the National Science Foundation (Grant 1247392) to Justin C. Strickland, and professional development funds from the University of Kentucky Department of Behavioral Science to William W. Stoops. These funding sources had no role in study design, data collection or analysis, or preparation and submission of the manuscript. Data from this project will be included in a poster presentation at the 2018 American Psychological Association Convention. We thank Robert Larson for his technical assistance.

FundersFunder number
University of Kentucky Department of Behavioral Science
National Science Foundation (NSF)1247392

    Keywords

    • Addiction
    • Cigarette
    • Cocaine
    • Consent
    • Mechanical Turk

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Clinical Psychology
    • Psychiatry and Mental health

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