Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort

Soo Kyung Park; Darwin L. Conwell; Phil A. Hart; Shuang Li; Kimberly Stello; Evan L. Fogel; William E. Fisher; Christopher E. Forsmark; Stephen J. Pandol; Walter G. Park; Mark Topazian; Jose Serrano; Santhi Swaroop Vege; Stephen K. Van Den Eeden; Liang Li; Dhiraj Yadav; Jami L. Saloman

doi:10.14309/ctg.0000000000000758

Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort

Soo Kyung Park, Darwin L. Conwell, Phil A. Hart, Shuang Li, Kimberly Stello, Evan L. Fogel, William E. Fisher, Christopher E. Forsmark, Stephen J. Pandol, Walter G. Park, Mark Topazian, Jose Serrano, Santhi Swaroop Vege, Stephen K. Van Den Eeden, Liang Li, Dhiraj Yadav, Jami L. Saloman

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

INTRODUCTION:Chronic Pancreatitis Prognosis Score (COPPS) was developed to discriminate disease severity and predict risk for future hospitalizations. In this cohort study, we evaluated if COPPS predicts the likelihood of hospitalization(s) in an American cohort.METHODS:The Chronic Pancreatitis, Diabetes, and Pancreatic Cancer consortium provided data and serum from subjects with chronic pancreatitis (N = 279). COPPS was calculated with baseline data and stratified by severity (low, moderate, and high). Primary endpoints included number and duration of hospitalizations during 12-month follow-up.RESULTS:The mean ± SD COPPS was 8.4 ± 1.6. COPPS correlated with all primary outcomes: hospitalizations for any reason (number: r = 0.15, P = 0.01; duration: r = 0.16, P = 0.01) and pancreas-related hospitalizations (number: r = 0.15, P = 0.02; duration: r = 0.13, P = 0.04). The severity distribution was 13.3% low, 66.0% moderate, and 20.8% high. 37.6% of subjects had ≥1 hospitalization(s) for any reason; 32.2% had ≥1 pancreas-related hospitalizations. All primary outcomes were significantly different between severity groups: hospitalizations for any reason (number, P = 0.004; duration, P = 0.007) and pancreas-related hospitalizations (number, P = 0.02; duration, P = 0.04). The prevalence of continued drinking at follow-up (P = 0.04) was higher in the low and moderate groups. The prevalence of anxiety at enrollment (P = 0.02) and follow-up (P < 0.05) was higher in the moderate and high groups.DISCUSSION:Statistically, COPPS significantly correlated with hospitalization outcomes, but the correlations were weaker than in previous studies, which may be related to the outpatient nature of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies cohort and lower prevalence of high severity disease. Studies in other prospective cohorts are needed to understand the full utility of COPPS as a potential tool for clinical risk assessment and intervention.

Original language	English
Pages (from-to)	e00758
Journal	Clinical and Translational Gastroenterology
Volume	15
Issue number	11
DOIs	https://doi.org/10.14309/ctg.0000000000000758
State	Published - Aug 13 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s).

Funding

This work was supported by the National Cancer Institute (NCI) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under award numbers: R21DK122293 and K01DK120737 (J.L.S), U01DK108288 (S.S.V. and M.T), U01DK108300 (W.G.P), U01DK108306 (D.Y), U01DK108314 (S.J.P), U01DK108323 (E.L.F), U01DK108326 (W.E.F), U01DK108327 (P.A.H. and D.L.C), U01DK108332 (S.K.V), U01DK108320 (C.E.F), and U01DK108328 (S.K.P., L.L). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funders	Funder number
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108328, U01DK108306, U01DK108327, U01DK108323, U01DK108326, U01DK108314, R21DK122293, U01DK108320, K01DK120737, U01DK108300, U01DK108332, U01DK108288
National Institute of Diabetes and Digestive and Kidney Diseases

Keywords

COPPS
chronic pancreatitis
clinical scoring system

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.14309/ctg.0000000000000758

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Park, S. K., Conwell, D. L., Hart, P. A., Li, S., Stello, K., Fogel, E. L., Fisher, W. E., Forsmark, C. E., Pandol, S. J., Park, W. G., Topazian, M., Serrano, J., Vege, S. S., Van Den Eeden, S. K., Li, L., Yadav, D., & Saloman, J. L. (2024). Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort. Clinical and Translational Gastroenterology, 15(11), e00758. https://doi.org/10.14309/ctg.0000000000000758

@article{31703de9b749472981b617badb267ff1,

title = "Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort",

abstract = "INTRODUCTION:Chronic Pancreatitis Prognosis Score (COPPS) was developed to discriminate disease severity and predict risk for future hospitalizations. In this cohort study, we evaluated if COPPS predicts the likelihood of hospitalization(s) in an American cohort.METHODS:The Chronic Pancreatitis, Diabetes, and Pancreatic Cancer consortium provided data and serum from subjects with chronic pancreatitis (N = 279). COPPS was calculated with baseline data and stratified by severity (low, moderate, and high). Primary endpoints included number and duration of hospitalizations during 12-month follow-up.RESULTS:The mean ± SD COPPS was 8.4 ± 1.6. COPPS correlated with all primary outcomes: hospitalizations for any reason (number: r = 0.15, P = 0.01; duration: r = 0.16, P = 0.01) and pancreas-related hospitalizations (number: r = 0.15, P = 0.02; duration: r = 0.13, P = 0.04). The severity distribution was 13.3\% low, 66.0\% moderate, and 20.8\% high. 37.6\% of subjects had ≥1 hospitalization(s) for any reason; 32.2\% had ≥1 pancreas-related hospitalizations. All primary outcomes were significantly different between severity groups: hospitalizations for any reason (number, P = 0.004; duration, P = 0.007) and pancreas-related hospitalizations (number, P = 0.02; duration, P = 0.04). The prevalence of continued drinking at follow-up (P = 0.04) was higher in the low and moderate groups. The prevalence of anxiety at enrollment (P = 0.02) and follow-up (P < 0.05) was higher in the moderate and high groups.DISCUSSION:Statistically, COPPS significantly correlated with hospitalization outcomes, but the correlations were weaker than in previous studies, which may be related to the outpatient nature of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies cohort and lower prevalence of high severity disease. Studies in other prospective cohorts are needed to understand the full utility of COPPS as a potential tool for clinical risk assessment and intervention.",

keywords = "COPPS, chronic pancreatitis, clinical scoring system",

author = "Park, \{Soo Kyung\} and Conwell, \{Darwin L.\} and Hart, \{Phil A.\} and Shuang Li and Kimberly Stello and Fogel, \{Evan L.\} and Fisher, \{William E.\} and Forsmark, \{Christopher E.\} and Pandol, \{Stephen J.\} and Park, \{Walter G.\} and Mark Topazian and Jose Serrano and Vege, \{Santhi Swaroop\} and \{Van Den Eeden\}, \{Stephen K.\} and Liang Li and Dhiraj Yadav and Saloman, \{Jami L.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",

year = "2024",

month = aug,

day = "13",

doi = "10.14309/ctg.0000000000000758",

language = "English",

volume = "15",

pages = "e00758",

journal = "Clinical and Translational Gastroenterology",

issn = "2155-384X",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

Park, SK, Conwell, DL, Hart, PA, Li, S, Stello, K, Fogel, EL, Fisher, WE, Forsmark, CE, Pandol, SJ, Park, WG, Topazian, M, Serrano, J, Vege, SS, Van Den Eeden, SK, Li, L, Yadav, D & Saloman, JL 2024, 'Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort', Clinical and Translational Gastroenterology, vol. 15, no. 11, pp. e00758. https://doi.org/10.14309/ctg.0000000000000758

TY - JOUR

T1 - Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort

AU - Park, Soo Kyung

AU - Conwell, Darwin L.

AU - Hart, Phil A.

AU - Li, Shuang

AU - Stello, Kimberly

AU - Fogel, Evan L.

AU - Fisher, William E.

AU - Forsmark, Christopher E.

AU - Pandol, Stephen J.

AU - Park, Walter G.

AU - Topazian, Mark

AU - Serrano, Jose

AU - Vege, Santhi Swaroop

AU - Van Den Eeden, Stephen K.

AU - Li, Liang

AU - Yadav, Dhiraj

AU - Saloman, Jami L.

PY - 2024/8/13

Y1 - 2024/8/13

N2 - INTRODUCTION:Chronic Pancreatitis Prognosis Score (COPPS) was developed to discriminate disease severity and predict risk for future hospitalizations. In this cohort study, we evaluated if COPPS predicts the likelihood of hospitalization(s) in an American cohort.METHODS:The Chronic Pancreatitis, Diabetes, and Pancreatic Cancer consortium provided data and serum from subjects with chronic pancreatitis (N = 279). COPPS was calculated with baseline data and stratified by severity (low, moderate, and high). Primary endpoints included number and duration of hospitalizations during 12-month follow-up.RESULTS:The mean ± SD COPPS was 8.4 ± 1.6. COPPS correlated with all primary outcomes: hospitalizations for any reason (number: r = 0.15, P = 0.01; duration: r = 0.16, P = 0.01) and pancreas-related hospitalizations (number: r = 0.15, P = 0.02; duration: r = 0.13, P = 0.04). The severity distribution was 13.3% low, 66.0% moderate, and 20.8% high. 37.6% of subjects had ≥1 hospitalization(s) for any reason; 32.2% had ≥1 pancreas-related hospitalizations. All primary outcomes were significantly different between severity groups: hospitalizations for any reason (number, P = 0.004; duration, P = 0.007) and pancreas-related hospitalizations (number, P = 0.02; duration, P = 0.04). The prevalence of continued drinking at follow-up (P = 0.04) was higher in the low and moderate groups. The prevalence of anxiety at enrollment (P = 0.02) and follow-up (P < 0.05) was higher in the moderate and high groups.DISCUSSION:Statistically, COPPS significantly correlated with hospitalization outcomes, but the correlations were weaker than in previous studies, which may be related to the outpatient nature of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies cohort and lower prevalence of high severity disease. Studies in other prospective cohorts are needed to understand the full utility of COPPS as a potential tool for clinical risk assessment and intervention.

AB - INTRODUCTION:Chronic Pancreatitis Prognosis Score (COPPS) was developed to discriminate disease severity and predict risk for future hospitalizations. In this cohort study, we evaluated if COPPS predicts the likelihood of hospitalization(s) in an American cohort.METHODS:The Chronic Pancreatitis, Diabetes, and Pancreatic Cancer consortium provided data and serum from subjects with chronic pancreatitis (N = 279). COPPS was calculated with baseline data and stratified by severity (low, moderate, and high). Primary endpoints included number and duration of hospitalizations during 12-month follow-up.RESULTS:The mean ± SD COPPS was 8.4 ± 1.6. COPPS correlated with all primary outcomes: hospitalizations for any reason (number: r = 0.15, P = 0.01; duration: r = 0.16, P = 0.01) and pancreas-related hospitalizations (number: r = 0.15, P = 0.02; duration: r = 0.13, P = 0.04). The severity distribution was 13.3% low, 66.0% moderate, and 20.8% high. 37.6% of subjects had ≥1 hospitalization(s) for any reason; 32.2% had ≥1 pancreas-related hospitalizations. All primary outcomes were significantly different between severity groups: hospitalizations for any reason (number, P = 0.004; duration, P = 0.007) and pancreas-related hospitalizations (number, P = 0.02; duration, P = 0.04). The prevalence of continued drinking at follow-up (P = 0.04) was higher in the low and moderate groups. The prevalence of anxiety at enrollment (P = 0.02) and follow-up (P < 0.05) was higher in the moderate and high groups.DISCUSSION:Statistically, COPPS significantly correlated with hospitalization outcomes, but the correlations were weaker than in previous studies, which may be related to the outpatient nature of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies cohort and lower prevalence of high severity disease. Studies in other prospective cohorts are needed to understand the full utility of COPPS as a potential tool for clinical risk assessment and intervention.

KW - COPPS

KW - chronic pancreatitis

KW - clinical scoring system

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UR - http://www.scopus.com/inward/citedby.url?scp=85201495012&partnerID=8YFLogxK

U2 - 10.14309/ctg.0000000000000758

DO - 10.14309/ctg.0000000000000758

M3 - Article

C2 - 39137098

AN - SCOPUS:85201495012

SN - 2155-384X

VL - 15

SP - e00758

JO - Clinical and Translational Gastroenterology

JF - Clinical and Translational Gastroenterology

IS - 11

ER -

Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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