Evaluation of High-dose Daptomycin in Children with Methicillin-resistant Staphylococcus aureus Bacteremia: A Case Series

Katie B. Olney; Manjunath P. Pai; Laura P. Stadler; David S. Burgess

doi:10.1097/INF.0000000000004871

Evaluation of High-dose Daptomycin in Children with Methicillin-resistant Staphylococcus aureus Bacteremia: A Case Series

Katie B. Olney, Manjunath P. Pai, Laura P. Stadler, David S. Burgess

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

Abstract

Daptomycin dosing in pediatrics has not been updated since initial approval to align with contemporary adult dosing recommendations. We observed lower than anticipated exposures with median 24-hour area under the curve of 378 mg·h/L [interquartile range (IQR): 368-413] in 4 children despite use of high doses (17-20 mg/kg/d). There is a critical need to reappraise daptomycin dosing in pediatric patients for Staphylococcus aureus bloodstream infections.

Original language	English
Article number	10.1097/INF.0000000000004871
Journal	Pediatric Infectious Disease Journal
DOIs	https://doi.org/10.1097/INF.0000000000004871
State	Accepted/In press - 2025

Bibliographical note

Publisher Copyright:
Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

daptomycin
pediatrics
pharmacodynamics
pharmacokinetics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000004871

Cite this

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abstract = "Daptomycin dosing in pediatrics has not been updated since initial approval to align with contemporary adult dosing recommendations. We observed lower than anticipated exposures with median 24-hour area under the curve of 378 mg·h/L [interquartile range (IQR): 368-413] in 4 children despite use of high doses (17-20 mg/kg/d). There is a critical need to reappraise daptomycin dosing in pediatric patients for Staphylococcus aureus bloodstream infections.",

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AU - Stadler, Laura P.

AU - Burgess, David S.

PY - 2025

Y1 - 2025

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AB - Daptomycin dosing in pediatrics has not been updated since initial approval to align with contemporary adult dosing recommendations. We observed lower than anticipated exposures with median 24-hour area under the curve of 378 mg·h/L [interquartile range (IQR): 368-413] in 4 children despite use of high doses (17-20 mg/kg/d). There is a critical need to reappraise daptomycin dosing in pediatric patients for Staphylococcus aureus bloodstream infections.

KW - daptomycin

KW - pediatrics

KW - pharmacodynamics

KW - pharmacokinetics

UR - https://www.scopus.com/pages/publications/105006999994

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JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

M1 - 10.1097/INF.0000000000004871

ER -

Evaluation of High-dose Daptomycin in Children with Methicillin-resistant Staphylococcus aureus Bacteremia: A Case Series

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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