Evaluation of interleukin-2 production and interleukin-2 receptor expression in dogs with generalized demodicosis

Stephen L. Lemarié, David W. Horohov

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The experimental hypothesis tested was that dogs with generalized demodicosis have significantly lower levels of interleukin-2 (IL-2) production and IL-2 receptor expression as compared with normal dogs. The specific objective of this study was to compare the production of IL-2 and IL-2 receptor expression of peripheral blood mononuclear cells in normal dogs and dogs with generalized demodicosis. Ten dogs with juvenile-onset generalized demodicosis were evaluated. Dogs with generalized demodicosis had a significantly lower in vitro lymphocyte blastogenesis response (P < 0.006), fewer cells expressing IL-2 receptors (P < 0.03), and decreased IL-2 production (P < 0.01) than control dogs.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalVeterinary Dermatology
Volume7
Issue number4
DOIs
StatePublished - Dec 1996

Keywords

  • Canine
  • Generalized demodicosis
  • Interleukin-2

ASJC Scopus subject areas

  • General Veterinary

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