TY - JOUR
T1 - Evaluation of interleukin-2 production and interleukin-2 receptor expression in dogs with generalized demodicosis
AU - Lemarié, Stephen L.
AU - Horohov, David W.
PY - 1996/12
Y1 - 1996/12
N2 - The experimental hypothesis tested was that dogs with generalized demodicosis have significantly lower levels of interleukin-2 (IL-2) production and IL-2 receptor expression as compared with normal dogs. The specific objective of this study was to compare the production of IL-2 and IL-2 receptor expression of peripheral blood mononuclear cells in normal dogs and dogs with generalized demodicosis. Ten dogs with juvenile-onset generalized demodicosis were evaluated. Dogs with generalized demodicosis had a significantly lower in vitro lymphocyte blastogenesis response (P < 0.006), fewer cells expressing IL-2 receptors (P < 0.03), and decreased IL-2 production (P < 0.01) than control dogs.
AB - The experimental hypothesis tested was that dogs with generalized demodicosis have significantly lower levels of interleukin-2 (IL-2) production and IL-2 receptor expression as compared with normal dogs. The specific objective of this study was to compare the production of IL-2 and IL-2 receptor expression of peripheral blood mononuclear cells in normal dogs and dogs with generalized demodicosis. Ten dogs with juvenile-onset generalized demodicosis were evaluated. Dogs with generalized demodicosis had a significantly lower in vitro lymphocyte blastogenesis response (P < 0.006), fewer cells expressing IL-2 receptors (P < 0.03), and decreased IL-2 production (P < 0.01) than control dogs.
KW - Canine
KW - Generalized demodicosis
KW - Interleukin-2
UR - http://www.scopus.com/inward/record.url?scp=4243082457&partnerID=8YFLogxK
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U2 - 10.1111/j.1365-3164.1996.tb00249.x
DO - 10.1111/j.1365-3164.1996.tb00249.x
M3 - Review article
AN - SCOPUS:4243082457
SN - 0959-4493
VL - 7
SP - 213
EP - 219
JO - Veterinary Dermatology
JF - Veterinary Dermatology
IS - 4
ER -