Abstract
The experimental hypothesis tested was that dogs with generalized demodicosis have significantly lower levels of interleukin-2 (IL-2) production and IL-2 receptor expression as compared with normal dogs. The specific objective of this study was to compare the production of IL-2 and IL-2 receptor expression of peripheral blood mononuclear cells in normal dogs and dogs with generalized demodicosis. Ten dogs with juvenile-onset generalized demodicosis were evaluated. Dogs with generalized demodicosis had a significantly lower in vitro lymphocyte blastogenesis response (P < 0.006), fewer cells expressing IL-2 receptors (P < 0.03), and decreased IL-2 production (P < 0.01) than control dogs.
| Original language | English |
|---|---|
| Pages (from-to) | 213-219 |
| Number of pages | 7 |
| Journal | Veterinary Dermatology |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1996 |
Keywords
- Canine
- Generalized demodicosis
- Interleukin-2
ASJC Scopus subject areas
- General Veterinary
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