Evaluation of multi-echo ICA denoising for task based fMRI studies: Block designs, rapid event-related designs, and cardiac-gated fMRI

Javier Gonzalez-Castillo, Puja Panwar, Laura C. Buchanan, Cesar Caballero-Gaudes, Daniel A. Handwerker, David C. Jangraw, Valentinos Zachariou, Souheil Inati, Vinai Roopchansingh, John A. Derbyshire, Peter A. Bandettini

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Multi-echo fMRI, particularly the multi-echo independent component analysis (ME-ICA) algorithm, has previously proven useful for increasing the sensitivity and reducing false positives for functional MRI (fMRI) based resting state connectivity studies. Less is known about its efficacy for task-based fMRI, especially at the single subject level. This work, which focuses exclusively on individual subject results, compares ME-ICA to single-echo fMRI and a voxel-wise T2 weighted combination of multi-echo data for task-based fMRI under the following scenarios: cardiac-gated block designs, constant repetition time (TR) block designs, and constant TR rapid event-related designs. Performance is evaluated primarily in terms of sensitivity (i.e., activation extent, activation magnitude, percent detected trials and effect size estimates) using five different tasks expected to evoke neuronal activity in a distributed set of regions. The ME-ICA algorithm significantly outperformed all other evaluated processing alternatives in all scenarios. Largest improvements were observed for the cardiac-gated dataset, where ME-ICA was able to reliably detect and remove non-neural T1 signal fluctuations caused by non-constant repetition times. Although ME-ICA also outperformed the other options in terms of percent detection of individual trials for rapid event-related experiments, only 46% of all events were detected after ME-ICA; suggesting additional improvements in sensitivity are required to reliably detect individual short event occurrences. We conclude the manuscript with a detailed evaluation of ME-ICA outcomes and a discussion of how the ME-ICA algorithm could be further improved. Overall, our results suggest that ME-ICA constitutes a versatile, powerful approach for advanced denoising of task-based fMRI, not just resting-state data.

Original languageEnglish
Pages (from-to)452-468
Number of pages17
JournalNeuroImage
Volume141
DOIs
StatePublished - Nov 1 2016

Bibliographical note

Funding Information:
This research was possible thanks to the support of the National Institute of Mental Health Intramural Research Program. Portions of this study used the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health, Bethesda, MD ( biowulf.nih.gov ). This study is part of NIH clinical protocol number NCT00001360 , protocol ID 93-M-0170 and annual report ZIAMH002783-14. Dr. Caballero-Gaudes was supported by the Spanish Ministry of Economy and Competitiveness , through grant PSI 2013-42343 Neuroimagen Multimodal and the Severo Ochoa Programme for Centres/Units of Excellence in R&D ( SEV-2015-490 ).

Publisher Copyright:
© 2016

Keywords

  • Block design
  • ME-ICA
  • Multi-echo fMRI
  • Rapid event related
  • Sensitivity

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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