Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens

Yosra A. Helmy; Dipak Kathayat; Loic Deblais; Vishal Srivastava; Gary, Jr. Closs; Robert J., II Tokarski; Oluwatosin Ayinde; James R. Fuchs; Gireesh Rajashekara

doi:10.1128/spectrum.00286-22

Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens

Yosra A. Helmy
, Dipak Kathayat
, Loic Deblais
, Vishal Srivastava
, Gary, Jr. Closs
, Robert J., II Tokarski
, Oluwatosin Ayinde
, James R. Fuchs
, Gireesh Rajashekara

Veterinary Science

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Microbiology spectrum
DOIs	https://doi.org/10.1128/spectrum.00286-22
State	E-pub ahead of print - May 18 2022

Funding

We thank Wilbur Ouma for the assistance with the bioinformatic analysis. We thank Matthew Bernier for the assistance with the metabolomic analysis. We thank Juliette Hanson, Megan Strother, and Sara Tallmadge for assistance with chicken experiments. The research in Rajashekara laboratory is supported by the U.S. Department of Agriculture (USDA), National Institute for Food and Agriculture (NIFA) (grants number 2015-68004-23131 and 2020-6701-31401), the Technology Commercialization Office (TCO) of The Ohio State University, and the Ohio State Innovation Foundation. We declare no competing interests.

Keywords

APEC
quorum sensing
inhibitors
anti-virulence
auto-inducer 2
QSI-5
sulfadimethoxine
5 '-methylthioadenosine
chickens

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10.1128/spectrum.00286-22

Cite this

Helmy, Y. A., Kathayat, D., Deblais, L., Srivastava, V., Closs, G. J., Tokarski, R. J. . II., Ayinde, O., Fuchs, J. R., & Rajashekara, G. (2022). Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens. Microbiology spectrum. Advance online publication. https://doi.org/10.1128/spectrum.00286-22

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title = "Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens",

keywords = "APEC, quorum sensing, inhibitors, anti-virulence, auto-inducer 2, QSI-5, sulfadimethoxine, 5 '-methylthioadenosine, chickens",

author = "Helmy, \{Yosra A.\} and Dipak Kathayat and Loic Deblais and Vishal Srivastava and Closs, \{Gary, Jr.\} and Tokarski, \{Robert J., II\} and Oluwatosin Ayinde and Fuchs, \{James R.\} and Gireesh Rajashekara",

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T1 - Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens

AU - Helmy, Yosra A.

AU - Kathayat, Dipak

AU - Deblais, Loic

AU - Srivastava, Vishal

AU - Closs, Gary, Jr.

AU - Tokarski, Robert J., II

AU - Ayinde, Oluwatosin

AU - Fuchs, James R.

AU - Rajashekara, Gireesh

PY - 2022/5/18

Y1 - 2022/5/18

KW - APEC

KW - quorum sensing

KW - inhibitors

KW - anti-virulence

KW - auto-inducer 2

KW - QSI-5

KW - sulfadimethoxine

KW - 5 '-methylthioadenosine

KW - chickens

U2 - 10.1128/spectrum.00286-22

DO - 10.1128/spectrum.00286-22

M3 - Article

SN - 2165-0497

JO - Microbiology spectrum

JF - Microbiology spectrum

ER -

Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens

Funding

Keywords

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