Evaluation of poly(amino acid)-based block catiomer polyplex micelles with a three-dimensional multicell tumor spheroid system

Muri Han; Younsoo Bae; Nobuhiro Nishiyama; Kazunori Kataoka

Evaluation of poly(amino acid)-based block catiomer polyplex micelles with a three-dimensional multicell tumor spheroid system

Muri Han, Younsoo Bae, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to conference › Paper › peer-review

Abstract

The gene transfection efficacies and cytotoxicity of various block catiomer polyplex micelles were evaluated by using three-dimensional multicellular tumor spheroid models. Poly(ethylene glycol)-block-polyaspartamide carrying 2-(2-aminoethyle) aminoethyl group as the side chain has demonstrated its high transfection efficiency and low toxicity. And this study also showed that a multicellular tumor spheroid model has a high potential as a novel evaluation system for the evaluation of polymeric gene vector.

Original language	English
Pages	2064
Number of pages	1
State	Published - 2006
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

Keywords

Block catiomers
Polyplex micelles
Spheroid

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Evaluation of poly(amino acid)-based block catiomer polyplex micelles with a three-dimensional multicell tumor spheroid system",

abstract = "The gene transfection efficacies and cytotoxicity of various block catiomer polyplex micelles were evaluated by using three-dimensional multicellular tumor spheroid models. Poly(ethylene glycol)-block-polyaspartamide carrying 2-(2-aminoethyle) aminoethyl group as the side chain has demonstrated its high transfection efficiency and low toxicity. And this study also showed that a multicellular tumor spheroid model has a high potential as a novel evaluation system for the evaluation of polymeric gene vector.",

keywords = "Block catiomers, Polyplex micelles, Spheroid",

author = "Muri Han and Younsoo Bae and Nobuhiro Nishiyama and Kazunori Kataoka",

year = "2006",

language = "English",

pages = "2064",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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TY - CONF

T1 - Evaluation of poly(amino acid)-based block catiomer polyplex micelles with a three-dimensional multicell tumor spheroid system

AU - Han, Muri

AU - Bae, Younsoo

AU - Nishiyama, Nobuhiro

AU - Kataoka, Kazunori

PY - 2006

Y1 - 2006

N2 - The gene transfection efficacies and cytotoxicity of various block catiomer polyplex micelles were evaluated by using three-dimensional multicellular tumor spheroid models. Poly(ethylene glycol)-block-polyaspartamide carrying 2-(2-aminoethyle) aminoethyl group as the side chain has demonstrated its high transfection efficiency and low toxicity. And this study also showed that a multicellular tumor spheroid model has a high potential as a novel evaluation system for the evaluation of polymeric gene vector.

AB - The gene transfection efficacies and cytotoxicity of various block catiomer polyplex micelles were evaluated by using three-dimensional multicellular tumor spheroid models. Poly(ethylene glycol)-block-polyaspartamide carrying 2-(2-aminoethyle) aminoethyl group as the side chain has demonstrated its high transfection efficiency and low toxicity. And this study also showed that a multicellular tumor spheroid model has a high potential as a novel evaluation system for the evaluation of polymeric gene vector.

KW - Block catiomers

KW - Polyplex micelles

KW - Spheroid

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UR - http://www.scopus.com/inward/citedby.url?scp=33749834314&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749834314

SP - 2064

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Evaluation of poly(amino acid)-based block catiomer polyplex micelles with a three-dimensional multicell tumor spheroid system

Abstract

Conference

Keywords

ASJC Scopus subject areas

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