Evaluation of poly(amino acid)-based block catiomer polyplex micelles with a three-dimensional multicell tumor spheroid system

Muri Han, Younsoo Bae, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to conferencePaperpeer-review

Abstract

The gene transfection efficacies and cytotoxicity of various block catiomer polyplex micelles were evaluated by using three-dimensional multicellular tumor spheroid models. Poly(ethylene glycol)-block-polyaspartamide carrying 2-(2-aminoethyle) aminoethyl group as the side chain has demonstrated its high transfection efficiency and low toxicity. And this study also showed that a multicellular tumor spheroid model has a high potential as a novel evaluation system for the evaluation of polymeric gene vector.

Original languageEnglish
Pages2064
Number of pages1
StatePublished - 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Conference

Conference55th SPSJ Annual Meeting
Country/TerritoryJapan
CityNagoya
Period5/24/065/26/06

Keywords

  • Block catiomers
  • Polyplex micelles
  • Spheroid

ASJC Scopus subject areas

  • Engineering (all)

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