Abstract
A goal of the cooperative agreement between the U.S. Food and Drug Administration and the Center for Tobacco Reference Products (CTRP) at the University of Kentucky was to produce a standard reference cigarette for researchers to further tobacco science. The 1R6F certified reference cigarette for analytical testing was developed to be typical of an American blend cigarette. The cigarettes have been used in proficiency testing (PT) schemes under the supervision of the CTRP since 2016 for a variety of parameters. Data were compared from 8 rounds of PT schemes submitted by participating laboratories, which include various international stakeholders comprised of academic institutions, federal research/regulatory laboratories, tobacco product manufacturers, and independent contract testing laboratories. Evaluation of the datasets for harmful and potentially harmful constituents (HPHCs) within the mainstream smoke of the 1R6F certified reference cigarette included tobacco-specific nitrosamines (TSNA), tar, nicotine, and carbon monoxide (TNCO), and Benzo[α]pyrene (BαP). Of the datasets evaluated, less than 5 % resulted in either a warning or alert, and less than 2 % resulted in an alert. Comparisons across multiple PT rounds revealed no significant differences in the consensus means of the tested parameters. Evaluation of data submitted by participating laboratories for multiple proficiency test rounds shows that the 1R6F certified reference cigarette is an acceptable material as a control reference for the analysis of HPHCs which is imperative since some stakeholders may be required to participate in, and receive satisfactory results, from PT for accreditation purposes.
Original language | English |
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Pages (from-to) | 69-76 |
Number of pages | 8 |
Journal | Accreditation and Quality Assurance |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2023 |
Bibliographical note
Funding Information:Funding for this work was made possible, in part, by the U.S. Food and Drug Administration through grant UC2FD005049, UC2FD005671 and UC2FD006890. The views expressed in written materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government. This research was supported by the Shared Resource Facilities of the University of Kentucky Markey Cancer Center (P30CA177558).
Funding Information:
Funding for this work was made possible, in part, by the U.S. Food and Drug Administration through grant UC2FD005049, UC2FD005671 and UC2FD006890. The views expressed in written materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government. This research was supported by the Shared Resource Facilities of the University of Kentucky Markey Cancer Center (P30CA177558).
Publisher Copyright:
© 2023, The Author(s).
Keywords
- 1R6F
- Harmful potentially harmful compounds
- Proficiency test
- Reference tobacco
- Tar, nicotine, and carbon monoxide
- Tobacco-specific nitrosamines
ASJC Scopus subject areas
- Chemistry (all)
- Chemical Engineering (all)
- Instrumentation
- Safety, Risk, Reliability and Quality